Department of Pathology and Radiology, University of Maryland Medical Center, Baltimore, MD, USA.
Pathol Res Pract. 2013 Jan 15;209(1):62-6. doi: 10.1016/j.prp.2012.10.009. Epub 2012 Dec 6.
Amyloid tumors presenting as lung masses are rare. We report 3 patients seen over a 2-year period with multiple lung masses, 2 that were suspicious for metastasis, and one in a patient with chest pain. Pathologic evaluation demonstrated amyloid tumor in each case. Two demonstrated a prominent macrophage giant cell reaction; scattered polyclonal plasma cells were present in two of the cases. PET scanning of 2 of the patients revealed an SUV of 1.9 and 4.0, respectively. Short-term follow-up revealed that none of the 3 cases were associated with lymphoproliferative disorders. This small series and a literature review suggest that pulmonary amyloidomas are usually isolated lesions, and that PET may show increased uptake simulating a neoplasm.
以肺部肿块为表现的淀粉样肿瘤较为罕见。我们报道了 3 例在 2 年期间出现多个肺部肿块的患者，其中 2 例疑似转移，1 例伴有胸痛。病理评估显示每例均为淀粉样肿瘤。2 例显示明显的巨噬细胞巨细胞反应；2 例中还存在散在的多克隆浆细胞。2 例患者的 PET 扫描显示 SUV 值分别为 1.9 和 4.0。短期随访显示，这 3 例均与淋巴增殖性疾病无关。这一小系列病例和文献复习表明，肺部淀粉样瘤通常为孤立性病变，而 PET 可能显示摄取增加，模拟肿瘤。
