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碳水化合物缀合卟啉二聚体：用于单光子和双光子光动力疗法的潜在应用的合成和光生物评价。

Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.

机构信息

Institut Curie, Section de Recherches, Bât 110-112, Centre Universitaire, F-91405 Orsay, France.

出版信息

Bioorg Med Chem. 2013 Jan 1;21(1):153-65. doi: 10.1016/j.bmc.2012.10.042. Epub 2012 Nov 3.

DOI:10.1016/j.bmc.2012.10.042
PMID:23218779
Abstract

We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality.

摘要

我们报告了生物共轭锌卟啉二聚体 1a-e 的合成，这些二聚体被设计为用于单光子和双光子激发光动力疗法的光敏剂。这些大环化合物被糖单位（葡萄糖、甘露糖、乳糖）取代，以靶向过度表达凝集素膜受体的肿瘤细胞。研究了它们的极性、单线态氧的产生和体外光细胞毒性，以确定它们的光动力治疗潜力。

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