Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Department of Biological and Agricultural Engineering and Institute for Nanoscience and Engineering University of Arkansas, Fayetteville, Arkansas 72701, United States.
ACS Appl Bio Mater. 2021 Feb 15;4(2):1432-1440. doi: 10.1021/acsabm.0c01324. Epub 2021 Jan 28.
The field of photodynamic therapy (PDT) has continued to show promise as a potential method for treating tumors. In this work a photosensitizer (PS) has been delivered to cancer cell lines for PDT by incorporation into the metal-organic framework (MOF) as an organic linker. By functionalizing the surface of MOF nanoparticles with maltotriose the PS can efficiently target cancer cells with preferential uptake into pancreatic and breast cancer cell lines. Effective targeting overcomes some current problems with PDT including long-term photosensitivity and tumor specificity. Developing a PS with optimal absorption and stability is one of the foremost challenges in PDT and the synthesis of a chlorin which is activated by long-wavelength light and is resistant to photo-bleaching is described. This chlorin-based MOF shows anti-cancer ability several times higher than that of porphyrin-based MOFs with little toxicity to normal cell lines and no dark toxicity.
光动力疗法（PDT）领域一直显示出作为治疗肿瘤的一种潜在方法的前景。在这项工作中，通过将光敏剂（PS）掺入金属-有机骨架（MOF）作为有机配体，将 PS 递送至癌细胞系以进行 PDT。通过用麦芽三糖官能化 MOF 纳米粒子的表面，PS 可以有效地靶向具有优先摄取胰腺癌细胞系和乳腺癌细胞系的癌症细胞。有效的靶向性克服了 PDT 中的一些当前问题，包括长期光敏感性和肿瘤特异性。开发具有最佳吸收和稳定性的 PS 是 PDT 的首要挑战之一，描述了一种由长波长光激活且抗光漂白的叶绿素的合成。这种基于叶绿素的 MOF 显示出的抗癌能力比基于卟啉的 MOF 高出数倍，对正常细胞系的毒性很小，没有暗毒性。
