Institut Curie, Section de Recherches, Bât 110-112, Centre Universitaire , F-91405 Orsay, France.
J Org Chem. 2014 Feb 7;79(3):1406-17. doi: 10.1021/jo402658h. Epub 2014 Jan 29.
In order to avoid side effects at the time of cancer eradication to the patients, the selectivity of treatments has become of strategic importance. In the case of photodynamic therapy (PDT), two-photon absorption combined with active targeting of tumors could allow both spatial and chemical selectivity. In this context, we present the synthesis, spectroscopic, and biological properties of a series of porphyrin-triphenylamine hybrids with excellent singlet oxygen production capacities and good two-photon absorption.
为了避免在癌症根治时对患者产生副作用，治疗的选择性变得具有战略重要性。在光动力疗法（PDT）的情况下，双光子吸收结合肿瘤的主动靶向，可以实现空间和化学选择性。在这种情况下，我们介绍了一系列具有优异单线态氧产生能力和良好双光子吸收的卟啉-三苯胺杂化物的合成、光谱和生物学性质。
