Delgado-Ortega Mario, Marc Daniel, Dupont Joëlle, Trapp Sascha, Berri Mustapha, Meurens François
Institut National de la Recherche Agronomique (INRA), UMR1282 Infectiologie et Santé Publique, F-37380 Nouzilly, France.
Vet Immunol Immunopathol. 2013 Jan 15;151(1-2):1-19. doi: 10.1016/j.vetimm.2012.11.008. Epub 2012 Nov 20.
As for most biological processes, the immune response to microbial infections has to be tightly controlled to remain beneficial for the host. Inflammation is one of the major consequences of the host's immune response. For its orchestration, this process requires a fine-tuned interplay between interleukins, endothelial cells and various types of recruited immune cells. Suppressors of cytokine signalling (SOCS) proteins are crucially involved in the complex control of the inflammatory response through their actions on various signalling pathways including the JAK/STAT and NF-κB pathways. Due to their cytokine regulatory functions, they are frequent targets for exploitation by infectious agents trying to escape the host's immune response. This review article aims to summarize our current knowledge regarding SOCS family members in the different mammalian species studied so far, and to display their complex molecular interactions with microbial pathogens.
对于大多数生物过程而言，对微生物感染的免疫反应必须受到严格控制，以对宿主保持有益。炎症是宿主免疫反应的主要后果之一。为了协调这一过程，该过程需要白细胞介素、内皮细胞和各种募集的免疫细胞之间进行精细调节的相互作用。细胞因子信号传导抑制因子（SOCS）蛋白通过其对包括JAK/STAT和NF-κB途径在内的各种信号通路的作用，在炎症反应的复杂控制中起着至关重要的作用。由于它们的细胞因子调节功能，它们经常成为试图逃避宿主免疫反应的感染因子利用的目标。这篇综述文章旨在总结我们目前对迄今为止所研究的不同哺乳动物物种中SOCS家族成员的了解，并展示它们与微生物病原体的复杂分子相互作用。
