HealthTell Inc., 145 South 79th Street, Chandler, AZ 85226, USA.
Trends Biotechnol. 2013 Jan;31(1):45-51. doi: 10.1016/j.tibtech.2012.10.012. Epub 2012 Dec 5.
Health is a complex interaction between metabolism, physiology, and immunity. Although it is difficult to define quantitatively, the activity of the humoral immune system provides a reasonable proxy for changes in health. Immunosignaturing is a microarray-based technology that quantitates the dynamics of circulating antibodies. Recent advancements in the field warrant a review of the technology. Here, we provide an introduction to the technique, evaluate the current progress, contrast similar technologies, and suggest applications that immunosignaturing could facilitate.
健康是新陈代谢、生理学和免疫系统之间复杂的相互作用。尽管它很难进行定量定义，但体液免疫系统的活性为健康变化提供了一个合理的替代指标。免疫特征分析是一种基于微阵列的技术，可定量检测循环抗体的动态变化。该领域的最新进展值得对该技术进行回顾。在这里，我们提供了该技术的介绍，评估了当前的进展，对比了类似的技术，并提出了免疫特征分析可能促进的应用。
