Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, United States.
Curr Opin Immunol. 2013 Apr;25(2):206-13. doi: 10.1016/j.coi.2012.11.003. Epub 2012 Dec 6.
N-acetyllactosaminyl glycans are key regulators of the vitality and effector function of antitumor T cells. When galectin-1 (Gal-1) binds N-acetyllactosamines on select membrane glycoproteins on antitumor T cells, these cells either undergo apoptosis or become immunoregulatory. Methods designed to antagonize expression or function of these N-acetyllactosamines on N-glycans and O-glycans have thus intensified. Since tumors can produce an abundance of Gal-1, Gal-1 is considered a critical factor for protecting tumor cells from T cell-mediated antitumor activity. Recent efforts have capitalized on the anti-N-acetyllactosamine action of fluorinated glucosamines to treat antitumor T cells, resulting in diminished Gal-1-binding and higher antitumor T cell levels. In this perspective, the prospect of fluorinated glucosamines in eliminating N-acetyllactosamines on antitumor T cells to boost antitumor immunity is presented.
N-乙酰乳糖胺聚糖是抗肿瘤 T 细胞活力和效应功能的关键调节剂。当半乳糖凝集素-1（Gal-1）与抗肿瘤 T 细胞上特定膜糖蛋白上的 N-乙酰乳糖胺结合时，这些细胞要么凋亡，要么成为免疫调节细胞。因此，设计了各种拮抗 N-糖链和 O-糖链上这些 N-乙酰乳糖胺的表达或功能的方法。由于肿瘤可以产生大量的 Gal-1，因此 Gal-1 被认为是保护肿瘤细胞免受 T 细胞介导的抗肿瘤活性的关键因素。最近的研究利用氟化葡萄糖胺的抗 N-乙酰乳糖胺作用来治疗抗肿瘤 T 细胞，导致 Gal-1 结合减少和抗肿瘤 T 细胞水平升高。从这个角度来看，提出了氟化葡萄糖胺消除抗肿瘤 T 细胞上的 N-乙酰乳糖胺以增强抗肿瘤免疫的前景。
