Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Nuclear Medicine, University Hospital Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
J Nucl Med. 2020 Oct;61(10):1419-1427. doi: 10.2967/jnumed.119.238279. Epub 2020 Aug 6.
With the ability to noninvasively image and monitor molecular processes within tumors, molecular imaging represents a fundamental tool for cancer scientists. In the current review, we describe emergent optical technologies for molecular imaging. We aim to provide the reader with an overview of the fundamental principles on which each imaging strategy is based, to introduce established and future applications, and to provide a rationale for selecting optical technologies for molecular imaging depending on disease location, biology, and anatomy. To accelerate clinical translation of imaging techniques, we also describe examples of practical applications in patients. Elevating these techniques into standard-of-care tools will transform patient stratification, disease monitoring, and response evaluation.
凭借在肿瘤内无创成像和监测分子过程的能力，分子成像代表了癌症科学家的基本工具。在目前的综述中，我们描述了新兴的光学分子成像技术。我们的目标是为读者提供一个概述，说明每种成像策略所基于的基本原则，介绍已建立的和未来的应用，并为根据疾病位置、生物学和解剖结构选择光学技术进行分子成像提供依据。为了加速成像技术的临床转化，我们还描述了在患者中实际应用的例子。将这些技术提升为标准的护理工具将改变患者分层、疾病监测和反应评估。
