Wang Xin, Nilsson David, Norberg Petronella
Acreo AB, Box 787, SE-601 17, Norrköping, Sweden.
Biochim Biophys Acta. 2013 Sep;1830(9):4398-401. doi: 10.1016/j.bbagen.2012.11.026. Epub 2012 Dec 6.
In biosensors with a fluid analyte, the integration of a microfluidic system, which guides the analyte into the sensing area, is critical. Quicker and economical ways to build up microfluidic systems will make point of care diagnostics viable. Printing is a low-cost technology that is increasingly used in emerging organic and flexible electronics and biosensors. In this paper, we present printed fluidic systems on flexible substrates made with pressure sensitive adhesive materials.
Printable pressure sensitive adhesive materials have been used for making microfluidic systems. Flexible substrates have been used, and two types of adhesive materials, one thermally dried and another UV curable, have been tested. Top sealing layer was laminated directly on top of the printed microfluidic structure. Flow tests were done with deionized water.
Flow tests with deionized water show that both adhesive materials are suitable for capillary flow driven fluidic devices. Flow test using water as dielectric material was also done successfully on a printed electrolyte gated organic field effect transistor with an integrated microfluidic system.
Due to its ease of process and low cost, printed microfluidic system is believed to find more applications in biosensing devices. This article is part of a Special Issue entitled Organic Bioelectronics-Novel Applications in Biomedicine.
在具有流体分析物的生物传感器中，引导分析物进入传感区域的微流体系统的集成至关重要。构建微流体系统的更快且经济的方法将使即时诊断成为可能。印刷是一种低成本技术，越来越多地用于新兴的有机和柔性电子以及生物传感器中。在本文中，我们展示了用压敏胶材料制成的柔性基板上的印刷流体系统。
可印刷的压敏胶材料已用于制造微流体系统。使用了柔性基板，并测试了两种类型的胶材料，一种是热干燥的，另一种是紫外线可固化的。顶部密封层直接层压在印刷的微流体结构顶部。用去离子水进行流动测试。
用去离子水进行的流动测试表明，两种胶材料都适用于毛细管流动驱动的流体装置。在具有集成微流体系统的印刷电解质门控有机场效应晶体管上，也成功地进行了以水作为介电材料的流动测试。
由于其易于加工和低成本，印刷微流体系统有望在生物传感装置中得到更多应用。本文是名为“有机生物电子学——在生物医学中的新应用”的特刊的一部分。
