年龄相关性黄斑变性的现有知识和趋势：今天的和未来的治疗方法。
Current knowledge and trends in age-related macular degeneration: today's and future treatments.
机构信息
Department of Ophthalmology, University of Colorado Health and Science Center, Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO, USA.
出版信息
Retina. 2013 Sep;33(8):1487-502. doi: 10.1097/IAE.0b013e318271f265.
PURPOSE
To address the most dynamic and current issues concerning today's treatment options and promising research efforts regarding treatment for age-related macular degeneration. This review is aimed to serve as a practical reference for more in-depth reviews on the subject.
METHODS
An online review of the database PubMed and Ovid were performed, searching for the key words age-related macular degeneration, AMD, VEGF, treatment, PDT, steroids, bevacizumab, ranibizumab, VEGF-trap, radiation, combined therapy, as well as their compound phrases. The search was limited to articles published since 1985. All returned articles were carefully screened, and their references were manually reviewed for additional relevant data. The web page www.clinicaltrials.gov was also accessed in search of relevant research trials.
RESULTS
A total of 363 articles were reviewed, including 64 additional articles extracted from the references. At the end, only 160 references were included in this review.
CONCLUSION
Treatment for age-related macular degeneration is a very dynamic research field. While current treatments are mainly aimed at blocking vascular endothelial growth factor, future treatments seek to prevent vision loss because of scarring. Promising efforts have been made to address the dry form of the disease, which has lacked effective treatment.
目的
针对与年龄相关性黄斑变性（AMD）治疗相关的当前最具动态性和最前沿的问题，以及有前景的研究进展进行探讨。本文旨在为该主题的更深入综述提供实用参考。
方法
在数据库 PubMed 和 Ovid 上进行在线检索，检索关键词为年龄相关性黄斑变性、AMD、VEGF、治疗、PDT、类固醇、贝伐单抗、雷珠单抗、VEGF 陷阱、放射治疗、联合治疗，及其复合词组。搜索范围限定为自 1985 年以来发表的文章。仔细筛选所有返回的文章，并对其参考文献进行手动审查，以获取更多相关数据。还访问了网页 www.clinicaltrials.gov，以查找相关的研究试验。
结果
共审查了 363 篇文章，其中包括从参考文献中提取的 64 篇额外文章。最后，只有 160 篇参考文献被纳入本综述。
结论
年龄相关性黄斑变性的治疗是一个非常活跃的研究领域。目前的治疗方法主要针对血管内皮生长因子（VEGF）的阻断，而未来的治疗方法则旨在预防因瘢痕形成导致的视力丧失。在治疗干性 AMD 方面，已经做出了有前景的努力，因为目前缺乏有效的治疗方法。
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