Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Nat Neurosci. 2013 Jan;16(1):13-5. doi: 10.1038/nn.3284. Epub 2012 Dec 9.
Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward excitation. The result of this circuit selectivity is a dynamic regulation in the temporal window for integration of excitatory thalamic input, thus revealing a new role for neurogliaform cells in shaping sensory processing.
尽管普遍认为神经胶质细胞产生空间无限制的广泛抑制，但我们在这里证明，它们的活动减弱了第四层桶状皮层中海马诱发的前馈抑制，但对前馈兴奋没有影响。这种电路选择性的结果是兴奋性丘脑输入整合的时间窗口的动态调节，从而揭示了神经胶质细胞在塑造感觉处理中的新作用。
