Deitmer T
Klinik und Poliklinik für Hals-, Nasen-Ohren-Heilkunde der Westfälischen Wilhelms-Universität Münster.
Laryngorhinootologie. 1990 Feb;69(2):98-101. doi: 10.1055/s-2007-998152.
Mucociliary transport in the subglottic region was assessed in 45 of 75 human larynges that had been removed for carcinoma. These were marked with India ink and observed through an operating microscope. Normal mucociliary pathways in this region are known to be symmetric, conducting all of the mucus of the bronchial tree effectively to the posterior commissure for passage into the hypopharynx. None of the examined larynges showed normal transport patterns. The alteration of mucociliary flow as an early effect of tumor development is not likely. It is therefore concluded that these abnormal mucociliary transport patterns existed before tumor development and wee probably genetically coded. Such an ineffective clearance of airborne pollutants from the subglottic space with prolonged contact times may promote carcinogenesis. This might explain the known variable risk for carcinogenic susceptibility.
在75例因癌症切除的人类喉部中，对其中45例的声门下区域的黏液纤毛运输进行了评估。这些喉部用印度墨水标记，并通过手术显微镜进行观察。已知该区域正常的黏液纤毛路径是对称的，能有效地将支气管树的所有黏液传导至后联合，以便进入下咽。所有检查的喉部均未显示出正常的运输模式。黏液纤毛流动的改变作为肿瘤发展的早期效应不太可能。因此得出结论，这些异常的黏液纤毛运输模式在肿瘤发展之前就已存在，并且可能是由基因编码的。声门下空间对空气传播污染物的这种无效清除以及延长的接触时间可能会促进致癌作用。这可能解释了已知的致癌易感性的可变风险。
