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一种新型静脉全身麻醉剂——乳化异氟醚:从实验室到临床。

A novel intravenous general anesthetic--emulsified isoflurane: from bench to bedside.

机构信息

Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Front Med. 2012 Dec;6(4):381-7. doi: 10.1007/s11684-012-0229-z. Epub 2012 Dec 7.

DOI:10.1007/s11684-012-0229-z
PMID:23224415
Abstract

Application of volatile anesthetics greatly alters modern medicine. There are obvious advantages of volatile anesthetics such as strong anesthetic potency, rapid onset and elimination through respiration system. Isoflurane is one of the most widely used volatile anesthetics in clinic. Emulsified isoflurane, the emulsion of isoflurane, is a novel intravenous general anesthetic. With the development of emulsified isoflurane in the past fifteen years, its utility has spread from intravenous general anesthesia to various fields including regional anesthesia, organ protection, as well as anesthetic pharmacological study. In this review, we will summarize literatures of emulsified isoflurane about its history, clinical application and future potential utility in the above mentioned fields.

摘要

挥发性麻醉剂的应用极大地改变了现代医学。挥发性麻醉剂具有麻醉效能强、通过呼吸系统快速起效和消除等明显优势。异氟醚是临床应用最广泛的挥发性麻醉剂之一。乳化异氟醚是异氟醚的乳液,是一种新型的静脉全身麻醉剂。随着乳化异氟醚在过去十五年中的发展,其用途已从静脉全身麻醉扩展到包括区域麻醉、器官保护以及麻醉药理学研究等各个领域。在这篇综述中,我们将总结关于乳化异氟醚的文献,概述其在上述领域中的历史、临床应用和未来潜在用途。

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A novel intravenous general anesthetic--emulsified isoflurane: from bench to bedside.一种新型静脉全身麻醉剂——乳化异氟醚:从实验室到临床。
Front Med. 2012 Dec;6(4):381-7. doi: 10.1007/s11684-012-0229-z. Epub 2012 Dec 7.
2
Comparison of subarachnoid anesthetic effect of emulsified volatile anesthetics in rats.大鼠乳化挥发性麻醉剂蛛网膜下腔麻醉效果的比较
Int J Clin Exp Pathol. 2014 Dec 1;7(12):8748-55. eCollection 2014.
3
The efficacy and safety of intravenous emulsified isoflurane in rats.大鼠静脉注射乳化异氟烷的疗效与安全性
Anesth Analg. 2006 Jan;102(1):129-34. doi: 10.1213/01.ane.0000189612.24147.07.
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Comparison of anaesthetic and analgesic effects of emulsified isoflurane used alone or combined with lidocaine and fentanyl in dogs.乳化异氟醚单独使用或与利多卡因和芬太尼联合使用对犬的麻醉和镇痛效果比较
N Z Vet J. 2014 May;62(3):123-9. doi: 10.1080/00480169.2013.859976. Epub 2013 Dec 17.
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Inhibition of voltage-gated sodium channels by emulsified isoflurane may contribute to its subarachnoid anesthetic effect in beagle dogs.乳化异氟醚抑制电压门控钠离子通道可能有助于其在比格犬中的蛛网膜下腔麻醉作用。
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The interaction between emulsified isoflurane and lidocaine is synergism in intravenous regional anesthesia in rats.乳化异氟烷和利多卡因在大鼠静脉局部麻醉中的相互作用是协同的。
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GABA Receptor/STEP61 Signaling Pathway May Be Involved in Emulsified Isoflurane Anesthesia in Rats.GABA 受体/STEP61 信号通路可能参与了乳化异氟醚麻醉大鼠的过程。
Int J Mol Sci. 2020 Jun 7;21(11):4078. doi: 10.3390/ijms21114078.
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Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits.静脉注射乳化卤代麻醉药可对家兔心肌梗死产生急性和延迟性预处理作用。
Anesthesiology. 2004 Nov;101(5):1160-6. doi: 10.1097/00000542-200411000-00016.
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Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats.乳化异氟醚增加利多卡因的惊厥阈值,并在大鼠惊厥后产生神经保护作用。
Anesth Analg. 2014 Feb;118(2):310-317. doi: 10.1213/ANE.0000000000000065.
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[Preferential delivery of emulsified isoflurane to peripheral nerves in goats].
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Mar;41(2):332-6.

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CNS Drugs. 2025 Aug 7. doi: 10.1007/s40263-025-01213-4.
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A Multicenter, Randomized, Double-Blind, Positive-Controlled, Non-Inferiority, Phase III Clinical Trial Evaluating the Efficacy and Safety of Emulsified Isoflurane for Anesthesia Induction in Patients.一项多中心、随机、双盲、阳性对照、非劣效性III期临床试验,评估乳化异氟烷用于患者麻醉诱导的有效性和安全性。
CNS Drugs. 2022 Dec;36(12):1301-1311. doi: 10.1007/s40263-022-00970-w. Epub 2022 Nov 16.
3

本文引用的文献

1
Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics.用于静脉输送挥发性全身麻醉剂的异常稳定的氟相乳液。
Anesthesiology. 2012 Mar;116(3):580-5. doi: 10.1097/ALN.0b013e3182475d4d.
2
Halothane-induced hepatitis: A forgotten issue in developing countries: Halothane-induced hepatitis.氟烷性肝炎:发展中国家一个被遗忘的问题:氟烷性肝炎
Hepat Mon. 2011 Jan;11(1):3-6.
3
Inhibition of voltage-gated sodium channels by emulsified isoflurane may contribute to its subarachnoid anesthetic effect in beagle dogs.
The Bioequivalence of Emulsified Isoflurane With a New Formulation of Emulsion: A Single-Center, Single-Dose, Double-Blinded, Randomized, Two-Period Crossover Study.
乳化异氟烷与新型乳剂配方的生物等效性:一项单中心、单剂量、双盲、随机、两期交叉研究。
Front Pharmacol. 2021 Mar 10;12:626307. doi: 10.3389/fphar.2021.626307. eCollection 2021.
乳化异氟醚抑制电压门控钠离子通道可能有助于其在比格犬中的蛛网膜下腔麻醉作用。
Reg Anesth Pain Med. 2011 Nov-Dec;36(6):553-9. doi: 10.1097/AAP.0b013e3182324d18.
4
Emulsified isoflurane preconditioning reduces lung injury induced by hepatic ischemia/reperfusion in rats.乳化异氟醚预处理减轻大鼠肝缺血/再灌注引起的肺损伤。
Int J Med Sci. 2011;8(5):353-61. doi: 10.7150/ijms.8.353. Epub 2011 Jun 8.
5
The interaction between emulsified isoflurane and lidocaine is synergism in intravenous regional anesthesia in rats.乳化异氟烷和利多卡因在大鼠静脉局部麻醉中的相互作用是协同的。
Anesth Analg. 2011 Aug;113(2):245-50. doi: 10.1213/ANE.0b013e31821e9797. Epub 2011 May 19.
6
[The sedative and hypnotic effects and safety of oral emulsified isoflurane in rats].[大鼠口服乳化异氟烷的镇静催眠作用及安全性]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Sep;41(5):862-4, 887.
7
Emulsified isoflurane preconditioning protects against liver and lung injury in rat model of hemorrhagic shock.乳化异氟醚预处理对失血性休克大鼠肝肺损伤的保护作用。
J Surg Res. 2011 Dec;171(2):783-90. doi: 10.1016/j.jss.2010.06.037. Epub 2010 Sep 8.
8
A model for the preferential delivery of isoflurane to the spinal cord of the goat.山羊脊髓中异氟醚优先传递的模型。
Vet J. 2011 Feb;187(2):239-44. doi: 10.1016/j.tvjl.2010.01.004. Epub 2010 Aug 23.
9
Reversible conduction block in isolated toad sciatic nerve by emulsified isoflurane.乳化异氟烷可逆阻断离体蟾蜍坐骨神经传导。
Anesth Analg. 2010 Apr 1;110(4):1024-9. doi: 10.1213/ANE.0b013e3181d2732f.
10
Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats.在大鼠离体心脏缺血再灌注损伤模型中,圣托马斯溶液提供的心脏保护作用通过乳化异氟醚得到增强。
J Cardiothorac Vasc Anesth. 2010 Feb;24(1):99-103. doi: 10.1053/j.jvca.2009.10.016.