Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam/Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.
J Autism Dev Disord. 2013 Aug;43(8):1784-97. doi: 10.1007/s10803-012-1724-4.
This study aimed to contribute to the Diagnostic and Statistical Manual (DSM) debates on the conceptualization of autism by investigating (1) whether empirically based distinct phenotypic profiles could be distinguished within a sample of mainly cognitively able children with pervasive developmental disorder (PDD), and (2) how profiles related to diagnoses and co-occurring behavioral and emotional problems. Six classes with distinct profiles were discerned. Three classes showed profiles not completely in line with the proposed DSM-5 conceptualization of autism. These classes included relatively many cognitively able individuals with PDD-not otherwise specified. However, profiles seemed to suit other diagnostic categories, such as social communication disorder. These alternative diagnoses could retain eligibility for services, and might adequately fit more specifically targeted interventions.
本研究旨在通过调查（1）在主要为认知能力正常的广泛性发育障碍（PDD）儿童样本中，是否可以区分基于经验的不同表型特征，以及（2）这些特征与诊断和共发行为和情绪问题的关系，为《精神疾病诊断与统计手册》（DSM）中关于自闭症的概念化的争论做出贡献。六个具有不同特征的类别被识别出来。三个类别的特征与DSM-5 提出的自闭症概念不完全一致。这些类别包括相对较多的具有未特指的 PDD 的认知能力正常个体。然而，这些特征似乎适合其他诊断类别，如社交沟通障碍。这些替代诊断可以保留获得服务的资格，并且可能更适合于更有针对性的干预措施。
