Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Cardiol J. 2012;19(6):618-24. doi: 10.5603/cj.2012.0114.
It is unclear whether gender and aging influence the characteristics of patients who undergo coronary artery bypass grafting (CABG).
We retrospectively reviewed a clinical database of 1,498 patients (male/female = 1133/365, age 67 ± 9 years) who underwent CABG at Fukuoka University Hospital from 1994 to 2010.
Male showed significantly younger, higher percentages (%) of smoking and hyperuricemia (HU), higher levels of serum creatinine, and lower % hypertension (HT) and diabetes mellitus (DM), and lower levels of left ventricular ejection fraction than female. In multivariate analysis, all parameters identified independent variables associated with the gender difference. Next, we divided the patients into 5 groups according to age, and each group was then separated by gender. The % of males significantly decreased with aging, whereas % female significantly increased. Although % smoking and estimated glomerular filtration rate (eGFR), and body mass index (BMI) in all patients, males and females significantly decreased with aging, HU, left ventricular end diastolic pressure and the number of significantly stenosed coronary vessels were not associated with gender or aging. Interestingly, % HT in all patients and males significantly increased with aging, whereas that in females was not associated with aging. Serum low-density lipoprotein cholesterol levels in males significantly decreased with aging, while those in all patients and females were not associated with aging. In this contemporary data set, the decreases in % smoking and eGFR with aging were common characteristics in male and female patients. In addition, there were gender and aging differences in % smoking, % HT, BMI and eGFR, whereas no differences were observed in % DM, % dyslipidemia or % HU.
Before CABG, high-risk patients with coronary artery disease who is going to undergo CABG may need to be managed more strictly considering to gender and age to avoid CABG.
性别和年龄是否影响行冠状动脉旁路移植术（CABG）患者的特征尚不清楚。
我们回顾性分析了 1994 年至 2010 年在福冈大学医院接受 CABG 的 1498 例患者（男/女=1133/365，年龄 67±9 岁）的临床数据库。
男性明显更年轻，吸烟和高尿酸血症（HU）的比例（%）更高，血清肌酐水平更高，高血压（HT）和糖尿病（DM）的比例（%）更低，左心室射血分数水平更低。多变量分析显示，所有参数均为与性别差异相关的独立变量。接下来，我们根据年龄将患者分为 5 组，然后根据性别将每组再分为两组。随着年龄的增长，男性的比例显著下降，而女性的比例显著增加。尽管所有患者、男性和女性的吸烟比例、估算肾小球滤过率（eGFR）和体重指数（BMI）随着年龄的增长而显著下降，但 HU、左心室舒张末期压和狭窄冠状动脉的数量与性别或年龄无关。有趣的是，所有患者和男性的 HT 比例随着年龄的增长而显著增加，而女性的 HT 比例与年龄无关。男性的血清低密度脂蛋白胆固醇水平随着年龄的增长而显著下降，而所有患者和女性的血清低密度脂蛋白胆固醇水平与年龄无关。在这个当代数据集中，吸烟比例和 eGFR 随年龄的下降是男性和女性患者的共同特征。此外，吸烟比例、HT 比例、BMI 和 eGFR 存在性别和年龄差异，而糖尿病、血脂异常或 HU 比例无差异。
在进行 CABG 之前，患有冠状动脉疾病且将要接受 CABG 的高危患者可能需要根据性别和年龄更严格地进行管理，以避免 CABG。
