Exact and Earth Sciences Dept., Universidade Federal de São Paulo, Rua São Nicolau, 210-CEP 09913-030, Diadema, SP, Brazil.
Biotechnol Prog. 2013 Jan-Feb;29(1):1-10. doi: 10.1002/btpr.1673. Epub 2013 Jan 17.
Carbon nanotubes, graphene and fullerenes are actual nanomaterials with many applications in different industrial areas, with increasing potentialities in the field of nanomedicine. Recently, different proactive approaches on toxicology and safety management have become the focus of intense interest once the industrial production of these materials had a significant growth in the last years, even though their short- and long-term behaviors are not yet fully understood. The most important concerns involving these carbon-based nanomaterials are their stability and potential effects of their life cycles on animals, humans, and environment. In this context, this mini review discuss the biodegradability of these materials, particularly through redox-enzymes, micro-organisms and cells, to contribute toward the design of biocompatible and biodegradable functionalized carbon nanostructures, in order to use these materials safely and with minimum impact on the environment.
碳纳米管、石墨烯和富勒烯是实际的纳米材料，在许多不同的工业领域有广泛的应用，在纳米医学领域具有越来越大的潜力。最近，毒理学和安全管理的不同积极方法已成为关注的焦点，因为这些材料的工业生产在过去几年中显著增长，尽管它们的短期和长期行为尚未完全了解。涉及这些碳基纳米材料的最重要的问题是它们的稳定性以及它们的生命周期对动物、人类和环境的潜在影响。在这种情况下，本综述讨论了这些材料的生物降解性，特别是通过氧化还原酶、微生物和细胞，以有助于设计生物相容和可生物降解的功能化碳纳米结构，以便安全地使用这些材料，对环境的影响最小。
