Deakin Nicholas O, Pignatelli Jeanine, Turner Christopher E
State University of New York Upstate Medical University, Syracuse, NY, USA.
Genes Cancer. 2012 May;3(5-6):362-70. doi: 10.1177/1947601912458582.
The paxillin family of intracellular scaffold proteins includes paxillin, Hic-5, and leupaxin, and all have been identified as key regulators of the cellular migration machinery in both 2- and 3-dimensional microenvironments. Herein, we provide insight into the roles of these proteins during tumorigenesis and metastasis, highlighting their functions in cancer initiation as well as tumor cell dissemination and survival. Furthermore, we speculate on the potential of paxillin family proteins as both future prognostic and therapeutic targets.
细胞内支架蛋白的桩蛋白家族包括桩蛋白、Hic-5和白细胞桩蛋白，并且所有这些蛋白均已被确定为二维和三维微环境中细胞迁移机制的关键调节因子。在此，我们深入探讨了这些蛋白在肿瘤发生和转移过程中的作用，强调了它们在癌症起始以及肿瘤细胞播散和存活中的功能。此外，我们推测了桩蛋白家族蛋白作为未来预后和治疗靶点的潜力。
