Li Zijian, Shao Ruonan, Xin Honglei, Zhu Yilin, Jiang Suyu, Wu Jiao, Yan Han, Jia Tongyu, Ge Mengyu, Shi Xiaofeng
The Second Affiliated Hospital of Nanjing Medical University, No.262, North Zhongshan Road, Nanjing 210003, China.
Biomolecules. 2025 Jan 24;15(2):173. doi: 10.3390/biom15020173.
Paxillin and kindlin are essential regulatory proteins involved in cell adhesion, migration, and signal transduction. Paxillin influences cytoskeletal dynamics by interacting with multiple signaling proteins, while kindlin regulates integrin activation, affecting adhesion and motility. This review examines the structures and functions of these proteins, focusing on their roles in cancer progression, immune response, and therapeutic potential. The cooperation between paxillin and kindlin in integrin activation and focal adhesion dynamics offers valuable insights into tumor metastasis, immune function, and tissue repair.
桩蛋白和纽带蛋白是参与细胞黏附、迁移和信号转导的重要调节蛋白。桩蛋白通过与多种信号蛋白相互作用来影响细胞骨架动力学，而纽带蛋白则调节整合素激活，影响黏附和运动。本文综述了这些蛋白的结构和功能，重点关注它们在癌症进展、免疫反应和治疗潜力方面的作用。桩蛋白和纽带蛋白在整合素激活和黏着斑动力学中的协同作用为肿瘤转移、免疫功能和组织修复提供了有价值的见解。
