Cas和NEDD9通过对细胞骨架的动态调控促进肿瘤进展。
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.
作者信息
Guerrero Michael S, Parsons J Thomas, Bouton Amy H
机构信息
University of Virginia School of Medicine, Charlottesville, VA, USA.
出版信息
Genes Cancer. 2012 May;3(5-6):371-81. doi: 10.1177/1947601912458585.
Abstract
The Cas family proteins, p130(Cas) (Cas) and NEDD9, are adaptor molecules that regulate cytoskeletal dynamics to promote multiple cellular processes, including migration, invasion, proliferation, and survival. Because these functions are also critical for tumor initiation, growth, and metastasis, Cas and NEDD9 are well positioned to contribute to these oncogenic processes. Indeed, mouse models of cancer show that these proteins function during multiple stages of disease progression. Furthermore, in many human cancers, high expression of Cas and NEDD9 is associated with advanced stage disease and is predictive of poor outcome. This review explores the contribution of Cas and NEDD9 during cellular transformation and neoplastic growth, tumor progression, metastasis, and the development of therapeutic resistance. Given these roles, Cas and NEDD9 may prove to be viable candidates for use as biomarkers and therapeutic targets.
摘要
Cas家族蛋白，即p130（Cas）（简称Cas）和NEDD9，是衔接分子，可调节细胞骨架动力学，以促进包括迁移、侵袭、增殖和存活在内的多种细胞过程。由于这些功能对肿瘤的起始、生长和转移也至关重要，Cas和NEDD9很可能在这些致癌过程中发挥作用。实际上，癌症小鼠模型表明这些蛋白在疾病进展的多个阶段发挥作用。此外，在许多人类癌症中，Cas和NEDD9的高表达与疾病晚期相关，并预示着不良预后。本综述探讨了Cas和NEDD9在细胞转化、肿瘤生长、肿瘤进展、转移以及治疗耐药性发展过程中的作用。鉴于这些作用，Cas和NEDD9可能被证明是用作生物标志物和治疗靶点的可行候选物。
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