Chenard Kristofer E, Teven Chad M, He Tong-Chuan, Reid Russell R
Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637, USA.
J Biomed Biotechnol. 2012;2012:601549. doi: 10.1155/2012/601549. Epub 2012 Nov 20.
Critical-size osseous defects cannot heal without surgical intervention and can pose a significant challenge to craniofacial reconstruction. Autologous bone grafting is the gold standard for repair but is limited by a donor site morbidity and a potentially inadequate supply of autologous bone. Alternatives to autologous bone grafting include the use of alloplastic and allogenic materials, mesenchymal stem cells, and bone morphogenetic proteins. Bone morphogenetic proteins (BMPs) are essential mediators of bone formation involved in the regulation of differentiation of osteoprogenitor cells into osteoblasts. Here we focus on the use of BMPs in experimental models of craniofacial surgery and clinical applications of BMPs in the reconstruction of the cranial vault, palate, and mandible and suggest a model for the use of BMPs in personalized stem cell therapies.
临界尺寸的骨缺损若无手术干预则无法愈合，会给颅面重建带来重大挑战。自体骨移植是修复的金标准，但受供区并发症以及自体骨供应可能不足的限制。自体骨移植的替代方法包括使用异体材料、同种异体材料、间充质干细胞和骨形态发生蛋白。骨形态发生蛋白（BMPs）是骨形成的重要介质，参与调节骨祖细胞向成骨细胞的分化。在此，我们聚焦于骨形态发生蛋白在颅面外科实验模型中的应用以及其在颅顶、腭和下颌骨重建中的临床应用，并提出一个在个性化干细胞治疗中使用骨形态发生蛋白的模型。
