Tashiro Toshiyuki, Seino Satoshi, Sato Toshihide, Matsuoka Ryosuke, Masuda Yasunobu, Fukui Naoshi
Department of Orthopaedic Surgery, JR Tokyo General Hospital, 2-1-3 Yoyogi, Shibuya-ku 151-8528, Tokyo, Japan.
ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928. Epub 2012 Nov 20.
This study was conducted to investigate the efficacy of oral hyaluronic acid (HA) administration for osteoarthritis (OA) in knee joints. Sixty osteoarthritic subjects (Kellgren-Lawrence grade 2 or 3) were randomly assigned to the HA or placebo group. The subjects in the HA group were given 200 mg of HA once a day everyday for 12 months, while the subjects in the placebo group were given placebo. The subjects in both groups were requested to conduct quadriceps strengthening exercise everyday as part of the treatment. The subjects' symptoms were evaluated by the Japanese Knee Osteoarthritis Measure (JKOM) score. The symptoms of the subjects as determined by the JKOM score improved with time in both the HA and placebo groups. This improvement tended to be more obvious with the HA group, and this trend was more obvious with the subjects aged 70 years or less. For these relatively younger subjects, the JKOM score was significantly better than the one for the placebo group at the 2nd and 4th months after the initiation of administration. Oral administration of HA may improve the symptoms of knee OA in patients aged 70 years or younger when combined with the quadriceps strengthening exercise.
本研究旨在探讨口服透明质酸（HA）治疗膝关节骨关节炎（OA）的疗效。60名骨关节炎患者（Kellgren-Lawrence分级为2级或3级）被随机分为HA组或安慰剂组。HA组患者每天服用200毫克HA，持续12个月，而安慰剂组患者服用安慰剂。两组患者均被要求每天进行股四头肌强化锻炼作为治疗的一部分。通过日本膝关节骨关节炎测量（JKOM）评分评估患者症状。HA组和安慰剂组患者的症状通过JKOM评分确定均随时间改善。HA组的改善趋势更为明显，且70岁及以下患者的这种趋势更明显。对于这些相对年轻的患者，给药后第2个月和第4个月时，JKOM评分显著优于安慰剂组。口服HA联合股四头肌强化锻炼可能改善70岁及以下膝关节OA患者的症状。
