Kang Shin Myung, Jang Young Rock, Yoon Hyun-Hwa, Kim Suji, Kim Eun Young, Ha Seung Yeon, Park Jeong-Woong
Department of Pulmonary and Critical Care Medicine, Gachon University Gil Hospital, Incheon, Korea.
Tuberc Respir Dis (Seoul). 2012 Mar;72(3):323-7. doi: 10.4046/trd.2012.72.3.323. Epub 2012 Mar 31.
5-Aminosalicylate agents are the main therapeutic agents for ulcerative colitis. Balsalazide is a prodrug of 5-aminosalicylate and has fewer side effects than the other 5-aminosalicylate agents. Pulmonary complications resembling granulomatosis with polyangiitis in ulcerative colitis are extremely rare. Here, we report a patient with ulcerative colitis on balsalazide presenting respiratory symptoms and multiple pulmonary nodules from a chest radiography that was pathologically diagnosed with a limited form of granulomatosis with polyangiitis with bronchiolitis obliterans organizing pneumonia-like variant. To our knowledge, this is the first report of a balsalazide-induced limited form of granulomatosis with polyangiitis with bronchiolitis obliterans organizing pneumonia-like variant.
5-氨基水杨酸制剂是溃疡性结肠炎的主要治疗药物。巴柳氮是5-氨基水杨酸的前体药物，与其他5-氨基水杨酸制剂相比副作用更少。溃疡性结肠炎中类似于肉芽肿性多血管炎的肺部并发症极为罕见。在此，我们报告一例服用巴柳氮的溃疡性结肠炎患者，出现呼吸道症状，胸部X线检查发现多个肺结节，经病理诊断为局限性肉芽肿性多血管炎合并闭塞性细支气管炎机化性肺炎样变异型。据我们所知，这是巴柳氮诱发的局限性肉芽肿性多血管炎合并闭塞性细支气管炎机化性肺炎样变异型的首例报告。
