CHUQ Medical Research Center. Quebec, Canada.
Neurotoxicology. 2012 Oct;33(5):1067-74. doi: 10.1016/j.neuro.2012.05.005.
Studies conducted in the Faeroe Islands and Japan suggest a negative impact of mercury on heart rate variability (HRV) among children while the results regarding blood pressure (BP) are less consistent.
To assess the impact of mercury on HRV and BP among Nunavik Inuit children.
A cohort of 226 children was followed from birth to 11 years old. Mercury concentration in cord blood and in blood and hair at 11 years old were used as markers of prenatal and childhood exposure, respectively. HRV was measured using ambulatory 2 h-Holter monitoring while BP was measured through a standardized protocol. Simple regression was used to assess the relationship of mercury to BP and HRV parameters. Multiple linear regressions were performed adjusting for covariates such as age, sex, birth weight, body mass index (BMI), height, total n-3 fatty acids, polychlorinated biphenyls (PCB 153), lead, selenium and maternal smoking during pregnancy.
Median cord blood mercury and blood mercury levels at 11 years old were 81.5 nmoL/L (IQR:45.0–140.0) and 14.5 nmol/L (IQR: 7.5–28.0), respectively. After adjusting for the covariates, child blood mercury was associated with low frequency (LF) (b = 0.21, p = 0.05), the standard deviation of R–R intervals (SDNN) (b = 0.26, p = 0.02), the standard deviation of R–R intervals measured over 5 min periods (SDANN) (b = 0.31, p = 0.01) and the coefficient of variation of R–R intervals (CVRR) (b = 0.06,p = 0.02). No significant association was observed with BP.
Mercury exposure during childhood seems to affect HRV among Nunavik Inuit children at school age.
法罗群岛和日本的研究表明，汞会对儿童的心率变异性（HRV）产生负面影响，而关于血压（BP）的结果则不太一致。
评估汞对努纳武特因纽特儿童 HRV 和 BP 的影响。
对 226 名儿童进行了从出生到 11 岁的随访。脐带血中的汞浓度和 11 岁时血液和头发中的汞浓度分别作为产前和儿童期暴露的标志物。使用动态 2 小时 Holter 监测测量 HRV，通过标准化方案测量 BP。简单回归用于评估汞与 BP 和 HRV 参数的关系。进行了多元线性回归，以调整协变量，如年龄、性别、出生体重、体重指数（BMI）、身高、总 n-3 脂肪酸、多氯联苯（PCB 153）、铅、硒和母亲在怀孕期间吸烟。
中位数脐带血汞和 11 岁时血液汞水平分别为 81.5 nmol/L（IQR：45.0-140.0）和 14.5 nmol/L（IQR：7.5-28.0）。在调整了协变量后，儿童血液汞与低频（LF）（b = 0.21，p = 0.05）、R-R 间期标准差（SDNN）（b = 0.26，p = 0.02）、5 分钟时间段内 R-R 间期标准差（SDANN）（b = 0.31，p = 0.01）和 R-R 间期变异系数（CVRR）（b = 0.06，p = 0.02）呈正相关。与 BP 无显著相关性。
儿童期暴露于汞似乎会影响努纳武特因纽特儿童在校年龄的 HRV。
