Axe santé publique et pratiques optimales en santé, Centre de recherche du CHU de Québec, Canada.
Environ Int. 2013 Sep;59:282-9. doi: 10.1016/j.envint.2013.06.019. Epub 2013 Jul 19.
Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations.
We examined the associations between polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides and hypertension among Inuit from Nunavik (Quebec, Canada).
A complete set of data was obtained for 315 Inuit≥18years who participated in the "Santé Québec" health survey that was conducted in the 14 villages of Nunavik in 1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their metabolites were measured in plasma samples using gas chromatography with electron capture detection. Blood pressure (BP) was measured using a standardized protocol and information regarding anti-hypertensive medication was obtained through questionnaires. The associations between log-transformed POPs and hypertension (systolic BP≥140mmHg, diastolic BP≥90mmHg or anti-hypertensive medication) were analyzed using multiple logistic regressions.
Total PCBs as well as the sum of non-dioxin-like PCBs were significantly associated with higher risk of hypertension. Furthermore, the risk of hypertension increased with higher plasma concentrations of congeners 101, 105, 138 and 187. Models adjusted for BP risk factors became significant after including n-3 polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury did not change the results. Regarding OC pesticides, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was associated with increased risk of hypertension while inverse associations were observed with p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), β-hexachlorocyclohexane (HCH) and oxychlordane.
Some PCB congeners were associated with higher risk of hypertension in this highly exposed population. Most associations became significant after including n-3 PUFAs in the models. However, the analyses of OC pesticides revealed divergent results, which need to be confirmed in further cohort and experimental studies.
最近的证据表明，接触持久性有机污染物（POPs）会增加暴露于环境中的人群患高血压的风险。在北极地区的人群中已经检测到高 POP 水平，并且暴露与高消费鱼类和海洋哺乳动物有关，这些都是这些人群的传统饮食。
我们研究了来自魁北克努纳武特地区因纽特人的多氯联苯（PCBs）、有机氯（OC）农药与高血压之间的关系。
我们获得了参加 1992 年在努纳武特地区 14 个村庄进行的“魁北克健康调查”的 315 名年龄在 18 岁及以上的因纽特人的完整数据集。使用气相色谱法和电子捕获检测，在血浆样本中测量了 14 种多氯联苯（PCBs）和 8 种 OC 农药或其代谢物。使用标准化方案测量血压（BP），并通过问卷获取抗高血压药物的信息。使用多因素逻辑回归分析了 log 转换后的 POPs 与高血压（收缩压≥140mmHg、舒张压≥90mmHg 或使用抗高血压药物）之间的关联。
总 PCBs 以及非二恶英样 PCBs 的总和与高血压的风险显著相关。此外，与同型物 101、105、138 和 187 的血浆浓度较高相关的高血压风险增加。在纳入 n-3 多不饱和脂肪酸（PUFAs）后，模型变得有意义，进一步调整铅和汞并没有改变结果。关于 OC 农药，p,p'-二氯二苯二氯乙烯（p,p'-DDE）与高血压风险增加相关，而 p,p'-二氯二苯三氯乙烷（p,p'-DDT）、β-六氯环己烷（HCH）和氧化氯丹则与高血压风险降低相关。
在这个高度暴露的人群中，一些 PCB 同型物与高血压的风险增加有关。在模型中纳入 n-3 PUFAs 后，大多数关联变得显著。然而，OC 农药的分析结果显示出不同的结果，需要在进一步的队列和实验研究中进行验证。
