Nasrin M, Miah M R A, Datta P G, Saleh A A, Anwar S, Saha K L
Department of Microbiology, Bangladesh Medical College, Dhaka.
Bangladesh Med Res Counc Bull. 2012 Aug;38(2):59-61. doi: 10.3329/bmrcb.v38i2.12882.
Tonsils are one of the important secondary lymphoid organ in immune system. It remains controversial whether tonsillectomy results in decreased serum immunoglobulin level. The purpose of this study was to observe the effect of tonsillectomy on humoral immunity parameters among the patients with tonsillar disease. Total group A 70 patients up to the age of 18 years, who were enrolled for tonsillectomy and 30 age matched children group B were included for comparative study. Serum IgG, IgM and IgA levels were measured in all 70 patients before tonsillectomy and in 56 patients who came for 1st follow-up after one month and 30 patients who came for 2nd follow up after three months of tonsillectomy. Serum IgG, IgM and IgA levels were also measured in group B children. Serum IgG, IgM and IgA levels in patients of group A did not show any significant difference in comparison to group B. One month after tonsillectomy the level of IgG was slightly decreased and IgM and IgA were increased compared to preoperative value but not statistically significant. All IgG, IgM and IgA were also not significantly altered in comparison to group B. Three months after tonsillectomy serum IgG, IgM and IgA level were found decreased in comparison to pre operative value and group B, among which difference of only IgG was significant. After tonsillectomy humoral parameters were found reduced but overall impact on humoral immune status was not significantly altered.
扁桃体是免疫系统中重要的二级淋巴器官之一。扁桃体切除术后血清免疫球蛋白水平是否降低仍存在争议。本研究的目的是观察扁桃体切除术对扁桃体疾病患者体液免疫参数的影响。共纳入70例18岁以下接受扁桃体切除术的患者作为A组，以及30例年龄匹配的儿童作为B组进行对比研究。在所有70例患者扁桃体切除术前、术后1个月前来进行首次随访的56例患者以及术后3个月前来进行第二次随访的30例患者中检测血清IgG、IgM和IgA水平。同时也检测了B组儿童的血清IgG、IgM和IgA水平。A组患者的血清IgG、IgM和IgA水平与B组相比无显著差异。扁桃体切除术后1个月，与术前值相比，IgG水平略有下降，IgM和IgA水平升高，但无统计学意义。与B组相比，所有IgG、IgM和IgA水平也无显著变化。扁桃体切除术后3个月，与术前值和B组相比，血清IgG、IgM和IgA水平均降低，其中仅IgG的差异具有统计学意义。扁桃体切除术后体液参数降低，但对体液免疫状态的总体影响无显著改变。
