Department of Biomedical Sciences - BRIC, University of Copenhagen, Copenhagen, Denmark.
Parasite Immunol. 2013 Mar-Apr;35(3-4):103-108. doi: 10.1111/pim.12023.
Multiple sclerosis is a chronic inflammatory CNS disease, which affects about 1 in 1000 individuals in the western world. During the last couple of decades, epidemiological data have accumulated, pointing towards increases in incidence. This has been suggested to be linked to the relatively high hygiene standards that exist in the western world, with reduced exposure to various pathogens, including parasites, as a consequence. Parasites are known to employ various immunomodulatory and anti-inflammatory strategies, which enable them to evade destruction by the immune system. This is most likely one of the reasons for the disease-dampening effects, reported in numerous studies investigating parasite infections and autoimmunity. This review will focus on recent advances in the field of parasites as beneficial immunomodulators, in multiple sclerosis and the animal model experimental autoimmune encephalomyelitis.
多发性硬化症是一种慢性炎症性中枢神经系统疾病，在西方世界，大约每 1000 人中就有 1 人会受到影响。在过去的几十年中，积累了大量的流行病学数据，表明发病率有所上升。这被认为与西方世界相对较高的卫生标准有关，因为人们接触各种病原体（包括寄生虫）的机会减少了。众所周知，寄生虫会采用各种免疫调节和抗炎策略，使其能够逃避免疫系统的破坏。这很可能是众多研究寄生虫感染与自身免疫的研究报告中提到的寄生虫具有疾病抑制作用的原因之一。本综述将重点介绍寄生虫作为有益的免疫调节剂在多发性硬化症和实验性自身免疫性脑脊髓炎动物模型中的最新进展。
