Chargari Cyrus, Moncharmont Coralie, Lévy Antonin, Guy Jean-Baptiste, Bertrand Gérald, Guilbert Matthieu, Rousseau Claire, Védrine Lionel, Alphonse Gersende, Toillon Robert-Alain, Rodriguez-Lafrasse Claire, Deutsch Eric, Magné Nicolas
Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie-radiothérapie, 74, boulevard de Port-Royal, 75230 Paris cedex, France.
Bull Cancer. 2012 Dec;99(12):1153-60. doi: 10.1684/bdc.2012.1666.
Cancer stem cells are a subject of increasing interest in oncology. In particular, several data suggest that cancer stem cells are involved in the mechanisms of tumor radioresistance, and may explain the therapeutic failures after radiotherapy. Because of its poor prognosis and high recurrence rate after irradiation, glioblastoma model is often studied in the search for new radiosensitizers. There are several preclinical data suggesting that cancer stem cells could be a potential therapeutic target for improving the biological effectiveness of radiation therapy. Through the example of glioblastoma, we review the main signaling pathways involved in the mechanisms of radiation resistance of cancer stem cells and for which pharmacological targeting could potentially enhance tumor radiosensitivity.
癌症干细胞是肿瘤学领域中越来越受关注的一个课题。特别是，一些数据表明癌症干细胞参与了肿瘤放射抗性的机制，并且可能解释放疗后的治疗失败。由于胶质母细胞瘤预后较差且放疗后复发率高，因此在寻找新的放射增敏剂时经常对其模型进行研究。有几项临床前数据表明，癌症干细胞可能是提高放射治疗生物学有效性的潜在治疗靶点。通过胶质母细胞瘤这个例子，我们回顾了癌症干细胞放射抗性机制中涉及的主要信号通路，针对这些信号通路进行药物靶向可能会增强肿瘤的放射敏感性。
