Rancoule Chloé, Espenel Sophie, Trone Jane-Chloé, Langrand-Escure Julien, Vallard Alexis, Rehailia-Blanchard Amel, El Meddeb Hamrouni Anis, Xia Yaxiong, Guy Jean-Baptiste, Ben-Mrad Majed, Magné Nicolas
Radiotherapy Department, Lucien Neuwirth Cancer Institute, Saint-Priest-en-Jarez, France.
Cellular and Molecular Radiobiology Laboratory, CNRS UMR 5822, IPNL, Villeurbanne, France.
Oncotarget. 2017 Jun 27;8(26):43543-43554. doi: 10.18632/oncotarget.16672.
Radiation-induced fibrosis is widely considered as a common but forsaken phenomenon that can lead to clinical sequela and possibly vital impairments. Lysophosphatidic acid is a bioactive lipid involved in fibrosis and probably in radiation-induced fibrosis as suggested in recent studies. Lysophosphatidic acid is also a well-described pro-oncogenic factor, involved in carcinogenesis processes (proliferation, survival, angiogenesis, invasion, migration). The present review highlights and summarizes the links between lysophosphatidic acid and radiation-induced fibrosis, lysophosphatidic acid and radioresistance, and proposes lysophosphatidic acid as a potential central actor of the radiotherapy therapeutic index. Besides, we hypothesize that following radiotherapy, the newly formed tumour micro-environment, with increased extracellular matrix and increased lysophosphatidic acid levels, is a favourable ground to metastasis development. Lysophosphatidic acid could therefore be an exciting therapeutic target, minimizing radio-toxicities and radio-resistance effects.
辐射诱导的纤维化被广泛认为是一种常见但被忽视的现象，它可导致临床后遗症并可能造成严重损害。溶血磷脂酸是一种生物活性脂质，参与纤维化过程，近期研究表明其可能也参与辐射诱导的纤维化。溶血磷脂酸也是一种广为人知的促癌因子，参与致癌过程（增殖、存活、血管生成、侵袭、迁移）。本综述着重介绍并总结了溶血磷脂酸与辐射诱导的纤维化之间的联系、溶血磷脂酸与放射抗性之间的联系，并提出溶血磷脂酸可能是放射治疗治疗指数的关键因素。此外，我们推测放疗后新形成的肿瘤微环境，其细胞外基质增加且溶血磷脂酸水平升高，是转移发展的有利条件。因此，溶血磷脂酸可能是一个令人兴奋的治疗靶点，可将放射毒性和放射抗性效应降至最低。
