Kanagawa Academy of Science and Technology (KAST), KSP East 404, Takatsu-ku, Kawasaki, Japan.
J Mater Sci Mater Med. 2013 Mar;24(3):611-21. doi: 10.1007/s10856-012-4834-9. Epub 2012 Dec 11.
The hydroxyapatite (HAp) powder preparation process was optimized to fabricate inositol phosphate-HAp (IP6-HAp) cement with enhanced mechanical properties. Starting HAp powders were synthesized via a wet chemical process. The effect of the powder preparation process on the morphology, crystallinity, median particle size, and specific surface area (SSA) of the cement powders was examined, together with the mechanical properties of the resulting cement specimens. The smallest crystallite and median particle sizes, and the highest SSA were obtained from ball-milling of as-synthesized HAp powder under wet conditions and then freeze-drying. IP6-HAp cement fabricated with this powder had a maximum compressive strength of 23.1 ± 2.1 MPa. In vivo histological studies using rabbit models revealed that the IP6-HAp cements were directly in contact with newly formed and host bones. Thus, the present chelate-setting HAp cement is promising for application as a novel paste-like artificial bone.
优化了羟基磷灰石 (HAp) 粉末的制备工艺，以制备具有增强机械性能的肌醇六磷酸-HAp（IP6-HAp）水泥。起始 HAp 粉末通过湿化学工艺合成。研究了粉末制备工艺对水泥粉末的形态、结晶度、中值粒径和比表面积（SSA）以及水泥试样的机械性能的影响。在湿条件下球磨合成的 HAp 粉末，然后冷冻干燥，得到最小的晶粒和中值粒径，以及最高的 SSA。用这种粉末制备的 IP6-HAp 水泥的最大抗压强度为 23.1 ± 2.1 MPa。使用兔模型的体内组织学研究表明，IP6-HAp 水泥直接与新形成的和宿主骨接触。因此，本螯合沉淀 HAp 水泥有望作为一种新型糊剂人工骨应用。
