Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
J Mater Sci Mater Med. 2013 Jun;24(6):1383-94. doi: 10.1007/s10856-013-4903-8. Epub 2013 Mar 8.
Novel biodegradable β-tricalcium phosphate (β-TCP) cements with anti-washout properties were created on the basis of chelate-setting mechanism of inositol phosphate (IP6) using β-TCP powders. The β-TCP powders were ball-milled using ZrO₂ beads for 0-6 h in the IP6 solutions with concentrations from 0 to 10,000 ppm. The chelate-setting β-TCP cement with anti-washout property was successfully fabricated by mixing the β-TCP powder ball-milled in 3,000 ppm IP6 solution for 3 h and 2.5 mass% Na₂HPO₄ solution, and compressive strength of the cement was 13.4 ± 0.8 MPa. An in vivo study revealed that the above cement was directly in contact with host and newly formed bones without fibrous tissue layers, and was resorbed by osteoclast-like cells on the surface of the cement. The chelate-setting β-TCP cement with anti-washout property is promising for application as a novel injectable artificial bone with both biodegradability and osteoconductivity.
新型可生物降解的β-磷酸三钙（β-TCP）水泥具有抗冲洗特性，是基于肌醇六磷酸（IP6）的螯合凝固机制，使用β-TCP 粉末制备的。β-TCP 粉末在 IP6 溶液中使用 ZrO₂ 珠进行球磨 0-6 小时，浓度从 0 到 10000ppm。通过混合在 3000ppm IP6 溶液中球磨 3 小时的β-TCP 粉末和 2.5 质量%的 Na₂HPO₄溶液，成功制备了具有抗冲洗性能的螯合凝固β-TCP 水泥，水泥的抗压强度为 13.4±0.8MPa。体内研究表明，上述水泥直接与宿主和新形成的骨骼接触，没有纤维组织层，并且被水泥表面的破骨样细胞吸收。具有抗冲洗性能的螯合凝固β-TCP 水泥有望作为一种新型可注射人工骨，兼具生物降解性和骨传导性。
