Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China.
J Clin Neurosci. 2013 Feb;20(2):233-7. doi: 10.1016/j.jocn.2011.12.037. Epub 2012 Dec 8.
The objective of this study was to determine the levels of aquaporin-4 (AQP4) antibodies in the cerebrospinal fluid (CSF) of patients meeting the diagnostic criteria for multiple sclerosis (MS) and to describe some of the clinical features of CSF-positive cases. Thirty-five patients fulfilling the diagnostic criteria for MS but not neuromyelitis optica were included in this study. AQP4 antibodies were detected using a cell-based assay. None of the serum samples were positive for AQP4 antibodies. Five CSF samples (14.3%, 5/35) were positive for AQP4 antibodies. All CSF-positive patients had atypical brain lesions in areas known to have high levels of AQP4 expression. CSF AQP4 antibody testing is an important diagnostic aid in patients meeting MS criteria but with atypical brain or spinal lesions and serum negative for AQP4 antibodies.
本研究旨在测定符合多发性硬化症（MS）诊断标准的患者脑脊液（CSF）中的水通道蛋白-4（AQP4）抗体水平，并描述 CSF 阳性病例的一些临床特征。本研究纳入了 35 名符合 MS 但不符合视神经脊髓炎诊断标准的患者。使用基于细胞的测定法检测 AQP4 抗体。没有血清样本对 AQP4 抗体呈阳性。5 份 CSF 样本（14.3%，5/35）对 AQP4 抗体呈阳性。所有 CSF 阳性患者的大脑病变部位都不典型，这些部位已知有高水平的 AQP4 表达。在符合 MS 标准但具有非典型脑或脊髓病变且血清 AQP4 抗体阴性的患者中，CSF AQP4 抗体检测是一种重要的诊断辅助手段。
