特发性正常压力脑积水患者中的 AQP4 自身抗体。

AQP4 autoantibodies in patients with idiopathic normal pressure hydrocephalus.

机构信息

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy; Neuro-oncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy.

Parkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

出版信息

J Neuroimmunol. 2020 Dec 15;349:577407. doi: 10.1016/j.jneuroim.2020.577407. Epub 2020 Sep 30.

DOI:10.1016/j.jneuroim.2020.577407

PMID:33032017

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients. We collected serum and cerebrospinal fluid (CSF) from 43 iNPH patients and 35 with other neurodegenerative conditions, and serum from 43 healthy subjects. All samples were tested for AQP4-IgG/IgA/IgM antibodies using a live cell-based assay. No patients or controls had serum/CSF AQP4-IgG/IgA. One/43 iNPH patient and 0/43 controls tested positive for serum AQP4-IgM. The AQP4-IgM-positive iNPH patient had no clinico-radiological distinctive features. AQP4 antibodies are unlikely to play a role in iNPH pathogenesis.

摘要

特发性正常压力脑积水（iNPH）是一种病因不明的常见神经退行性疾病。iNPH 患者存在水通道蛋白 4（AQP4）选择性缺失。我们收集了 43 例 iNPH 患者、35 例其他神经退行性疾病患者和 43 例健康对照者的血清和脑脊液（CSF），并使用活细胞检测法检测所有样本的 AQP4-IgG/IgA/IgM 抗体。没有患者或对照者的血清/CSF 中存在 AQP4-IgG/IgA。1/43 例 iNPH 患者和 0/43 例对照者的血清 AQP4-IgM 检测呈阳性。该例 AQP4-IgM 阳性的 iNPH 患者无明显临床和影像学特征。AQP4 抗体不太可能在 iNPH 的发病机制中发挥作用。