Department of Medicine, School of Medicine, University of California San Diego., La Jolla, CA 92093-0682, USA.
Curr Atheroscler Rep. 2013 Jan;15(1):296. doi: 10.1007/s11883-012-0296-2.
Even though it has been recognized for some time that the lesions of atherosclerosis begin in childhood, there has been reluctance to recommend intervention, especially intervention with drugs, before the age of 50 years. Recent evidence, particularly evidence from human genetics, has greatly strengthened the case for earlier intervention to correct hypercholesterolemia and other risk factors. This report briefly reviews some of the emerging lines of evidence that are helping us reach a consensus on when and how we should intervene.
尽管人们已经认识到动脉粥样硬化的病变始于儿童期，但在 50 岁之前，人们一直不愿意推荐进行干预，尤其是药物干预。最近的证据，特别是来自人类遗传学的证据，极大地增强了更早干预以纠正高胆固醇血症和其他危险因素的理由。本报告简要回顾了一些新出现的证据线索，这些线索帮助我们就何时以及如何进行干预达成了共识。
