Lenko H L, Perheentupa J, Söderholm A
Acta Paediatr Scand Suppl. 1979;277:57-63. doi: 10.1111/j.1651-2227.1979.tb06193.x.
Spontaneous growth was analysed in a group of 55 girls with Turner's syndrome and various karyotypes. Their variation in height and its dependence on parental height were similar to that of normal girls. At all ages, the 45,X karyotype was associated with slightly greater mean stature than the other karyotypes together. The bone ages lagged progressively behind from 10 years onwards. Twenty-five patients aged between 9.1 and 17.2 years were given fluoxymesterone, 0.06-0.17 mg/kg daily, for at least 1 year. Their height velocities increased significantly. This brought about a clear psychological benefit. Their final heights were predicted before and after therapy, with a new method based on the spontaneous growth and bone maturation of our patients. The response was individually variable but, on average, the patients gained in predicted height from the therapy. This effect was not lost during a posttreatment year. Abnormal lowering of the voice occurred in patients receiving greater than or equal to 0.15 mg/kg fluoxymesterone daily, but never with less than 0.13 mg/kg. No other adverse effects appeared. Thus, fluoxymesterone is useful for promoting growth in girls with Turner's syndrome.
对一组55名患有特纳综合征且具有不同核型的女孩的自然生长情况进行了分析。她们身高的变化及其与父母身高的关系与正常女孩相似。在所有年龄段，45,X核型患者的平均身高略高于其他核型患者的平均身高总和。从10岁起，骨龄逐渐落后。25名年龄在9.1至17.2岁之间的患者每天服用氟羟甲睾酮，剂量为0.06 - 0.17毫克/千克，持续至少1年。她们的身高增长速度显著加快。这带来了明显的心理益处。采用基于我们患者自然生长和骨骼成熟情况的新方法，在治疗前后预测了她们的最终身高。反应存在个体差异，但总体而言，患者通过治疗在预测身高上有所增加。这种效果在治疗后的一年中并未消失。每天服用氟羟甲睾酮剂量大于或等于0.15毫克/千克的患者出现了声音异常低沉的情况，但每天服用剂量低于0.13毫克/千克时从未出现。未出现其他不良反应。因此，氟羟甲睾酮对促进特纳综合征女孩的生长有用。
