Department of Biochemistry, University of Kerala, Trivandrum, India.
Immunopharmacol Immunotoxicol. 2013 Apr;35(2):282-91. doi: 10.3109/08923973.2012.742534. Epub 2012 Dec 14.
The role of commercially available lycopene (all-trans) from tomato in controlling arthritis has been reported. Even though many reports are available that the cis form of lycopene is more biologically active, no report seems to be available on lycopene (cis and trans) isolated from an easily available and culturable sources. In the present study, the anti-arthritic effect of lycopene (cis and trans) from the algae Chlorella marina (AL) has been compared with lycopene (all-trans) from tomato (TL) and indomethacin (Indo). Arthritis (CIA) was developed in male Sprague dawley rats by collagen and the following parameters were studied. The activities of inflammatory marker enzymes like cyclooxygenase (COX), lipoxygenase (LOX) and myeloperoxidase (MPO) were found to be decreased on treatment with AL when compared to TL and Indo. Changes in Erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, red blood cells (RBC) count, hemoglobin (Hb), C-reactive protein (CRP), rheumatoid factor (RF), and ceruloplasmin levels observed in the blood of arthritic animals were brought back to normal by AL when compared to TL and Indo. Histopathology of paw and joint tissues showed marked reduction in edema on supplementation of AL. Thus these results indicate the potential beneficiary effect of algal lycopene on collagen induced arthritis in rats when compared to TL and even to the commonly used anti-inflammatory drug indomethacin. Therefore lycopene from C. marina would be recommended as a better natural source with increased activity and without side effects in the treatment of anti-inflammatory diseases.
已有报道称，商业化番茄来源的全反式番茄红素（lycopene）可用于控制关节炎。尽管有许多报道称顺式番茄红素的生物活性更高，但似乎没有关于从易于获得和可培养的来源分离出的顺式和反式番茄红素的报道。在本研究中，比较了来自绿藻（Chlorella marina）的番茄红素（顺式和反式）（AL）与番茄（TL）和消炎痛（Indo）的抗关节炎作用。通过胶原蛋白在雄性 Sprague dawley 大鼠中诱发关节炎（CIA），并研究了以下参数。与 TL 和 Indo 相比，AL 治疗可降低炎症标志物酶如环加氧酶（COX）、脂加氧酶（LOX）和髓过氧化物酶（MPO）的活性。与 TL 和 Indo 相比，AL 可使关节炎动物血液中的红细胞沉降率（ESR）、白细胞（WBC）计数、红细胞（RBC）计数、血红蛋白（Hb）、C-反应蛋白（CRP）、类风湿因子（RF）和铜蓝蛋白水平的变化恢复正常。与 TL 和 Indo 相比，补充 AL 可使爪和关节组织的组织病理学中的水肿明显减少。因此，这些结果表明，与 TL 甚至与常用的抗炎药消炎痛相比，藻类番茄红素对胶原诱导的大鼠关节炎具有潜在的有益作用。因此，建议将绿藻来源的番茄红素作为一种更好的天然来源，其具有更高的活性且无副作用，可用于治疗抗炎疾病。
