Department of Pathology and NYU Cancer Institute, NYU School of Medicine, Langone Medical Center, 550 First Avenue, New York, New York 10016, USA.
Nat Rev Immunol. 2013 Jan;13(1):23-33. doi: 10.1038/nri3361. Epub 2012 Dec 14.
Work on the mechanisms of fetomaternal tolerance has undergone a renaissance in recent years, and the general outlines of a solution to this long-standing paradox of 'transplantation' immunology have come into view. Here, we discuss several mechanisms, recently described in mice, that either minimize the activation of maternal T cells with fetal or placental specificity, or minimize the possibility that such T cells, if activated, are able to harm the fetus. The T cell response to antigens expressed by the conceptus serves as a paradigm for the study of tissue-specific immune tolerance and is relevant to the pathogenesis of immune-mediated pregnancy complications.
近年来，对胎母免疫耐受机制的研究又出现了新的进展，解决这一长期存在的“移植”免疫学悖论的大致方案已初见端倪。在这里，我们讨论了几种在小鼠中最近描述的机制，这些机制要么最小化了具有胎儿或胎盘特异性的母体 T 细胞的激活，要么最小化了这些 T 细胞如果被激活，是否能够伤害胎儿的可能性。针对胚胎表达抗原的 T 细胞反应为研究组织特异性免疫耐受提供了范例，并且与免疫介导的妊娠并发症的发病机制相关。
