Department of Clinical Physiopathology, Section of Radiodiagnostics, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
J Magn Reson Imaging. 2013 Aug;38(2):365-70. doi: 10.1002/jmri.23978. Epub 2012 Dec 13.
To prospectively evaluate the effect of gadoxetic acid (Gd-EOB-DTPA; Primovist, Bayer-Schering, Berlin, Germany) on quantitative diffusion-weighted imaging (DWI) using the Le Bihan IntraVoxel Incoherent Motion model and considering separately the following parameters: slow diffusion coefficient (D), fast diffusion coefficient (D*), perfusion fraction (PF), and apparent diffusion coefficient (ADC).
Twenty-four consecutive patients were submitted to the same magnetic resonance (MR)-DWI acquisition before and after gadoxetic acid administration. Patients were divided into four groups according to the time at which the DW sequence was repeated, then 5, 10, 15, 20 minutes after contrast agent administration. A total of 48 manually drawn regions of interest (ROIs) of about 1200 pixels were placed in the middle right liver lobe. The mean and standard deviation (SD) were calculated in each group/patient for every DWI-related parameter. Analysis of variance was performed (threshold P = 0.05). Bonferroni and Games-Howell post-hoc tests were applied if significant differences were found among groups; otherwise, data were averaged together.
D, D*, PF, and ADC did not show any significant difference before and after contrast agent administration, at any time.
It is possible to perform DW acquisitions after gadoxetic acid administration without any significant variation of the values of DW-related parameters under consideration in this study.
前瞻性评估钆塞酸二钠（Gd-EOB-DTPA；普美显，拜耳先灵，柏林，德国）对使用 Le Bihan 体素内不相干运动模型进行定量扩散加权成像（DWI）的影响，并分别考虑以下参数：慢扩散系数（D）、快扩散系数（D*）、灌注分数（PF）和表观扩散系数（ADC）。
24 例连续患者在注射钆塞酸二钠前后接受相同的磁共振（MR）-DWI 采集。根据 DW 序列重复的时间，将患者分为四组，分别为注射后 5、10、15、20 分钟。在右肝中叶共手动绘制了约 1200 个像素的 48 个感兴趣区（ROI）。在每组/每位患者中，计算了每个 DWI 相关参数的平均值和标准差（SD）。如果组间存在显著差异，则进行方差分析（阈值 P = 0.05）。如果发现组间存在显著差异，则应用 Bonferroni 和 Games-Howell 事后检验；否则，将数据平均在一起。
在任何时间，D、D*、PF 和 ADC 在注射对比剂前后均无显著差异。
在注射钆塞酸二钠后进行 DW 采集是可行的，在本研究中考虑的 DW 相关参数值没有明显变化。
