Akagi Motonori, Nakamura Yuko, Higaki Toru, Matsubara Yoshiko, Terada Hiroaki, Honda Yukiko, Tatsugami Fuminari, Baba Yasutaka, Iida Makoto, Awai Kazuo
From the Diagnostic Radiology, Hiroshima University, Hiroshima, Japan.
J Comput Assist Tomogr. 2018 May/Jun;42(3):373-379. doi: 10.1097/RCT.0000000000000702.
To compare the utility of high-precision computed diffusion-weighted imaging (hc-DWI) and conventional computed DWI (cc-DWI) for the diagnosis of hepatocellular carcinoma (HCC) at 3 T.
We subjected 75 HCC patients to DWI (b-value 150 and 600 s/mm). To generate hc-DWI we applied non-rigid image registration to avoid the mis-registration of images obtained with different b-values. We defined c-DWI with a b-value of 1500 s/mm using DWI with b-value 150 and 600 s/mm as cc-DWI, and c-DWI with b-value 1500 s/mm using registered DWI with b-value 150 and 600 s/mm as hc-DWI. A radiologist recorded the contrast ratio (CR) between HCC and the surrounding hepatic parenchyma.
The CR for HCC was significantly higher on hc- than cc-DWIs (median 2.0 vs. 1.8, P < 0.01).
The CR of HCC can be improved with image registration, indicating that hc-DWI is more useful than cc-DWI for the diagnosis of HCC.
比较高精度计算机扩散加权成像（hc-DWI）和传统计算机扩散加权成像（cc-DWI）在3T场强下对肝细胞癌（HCC）的诊断效用。
我们对75例HCC患者进行了扩散加权成像（b值为150和600 s/mm²）。为生成hc-DWI，我们应用了非刚性图像配准以避免不同b值获得的图像配准错误。我们将使用b值为150和600 s/mm²的扩散加权成像定义为b值为1500 s/mm²的c-DWI作为cc-DWI，将使用配准后的b值为150和600 s/mm²的扩散加权成像定义为b值为1500 s/mm²的c-DWI作为hc-DWI。一名放射科医生记录了HCC与周围肝实质之间的对比率（CR）。
hc-DWI上HCC的CR显著高于cc-DWI（中位数2.0对1.8，P < 0.01）。
图像配准可提高HCC的CR，表明hc-DWI在HCC诊断中比cc-DWI更有用。
