Sanz Ginés, Fuster Valentin
National Center for Cardiovascular Research CNIC, Madrid, Spain.
Mt Sinai J Med. 2012 Nov-Dec;79(6):683-8. doi: 10.1002/msj.21355.
Cardiovascular-disease prevention is often inadequate due to several factors. Lack of professional adherence to guidelines, unaffordable medication, and lack of patients' adherence to treatment are the most important. It has been suggested that an affordable, fixed-dose combination drug containing evidence-based active compounds could improve cardiovascular prevention by improving patients' adherence to treatment. The available evidence suggests that the polypill strategy can achieve this objective and it will gain a place in the therapeutic armamentarium for the prevention of cardiovascular events in patients at high risk.
由于多种因素，心血管疾病的预防往往不足。缺乏专业人员对指南的遵循、药物费用过高以及患者对治疗的依从性差是最重要的因素。有人提出，一种含有循证活性成分的价格可承受的固定剂量复方药物，通过提高患者对治疗的依从性，可能会改善心血管疾病的预防。现有证据表明，多效药丸策略可以实现这一目标，并且它将在预防高危患者心血管事件的治疗手段中占据一席之地。
