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[原发性支气管癌的手术。不同类型的切除术:技术问题、随访结果——延伸至隆突的肺切除术及支气管切除-吻合术的现状]

[Surgery of primary bronchial cancer. Different types of excisions: technical problems, follow-up results--status of pneumonectomies extended to the carina and bronchial resection-anastomoses].

作者信息

Levasseur P, Regnard J F

机构信息

Service de chirurgie thoracique et vasculaire, Centre chirurgical Marie-Lannelongue, Le Plessis Robinson, France.

出版信息

Helv Chir Acta. 1990 Jan;56(5):711-7.

PMID:2323947
Abstract

Surgery is the best solution for primary lung cancer. Surgery must be very large when necessary and must be as limited as possible when pulmonary function is poor. Surgery obtains the best results in primary lung cancer but must be associated with adjuvant therapy when necessary and specially in N2 tumors. In our experience in Marie Lannelongue Center we operated 5890 primary lung cancers between 1966 and 1987 (2255 lobectomies and 2240 pneumonectomies). Our long-term results are 38% at three years and 31% at five years. Extended surgery has been done in many patients. Chest wall resection is used when necessary associated to the lung resection. Carina resection must be used also if necessary. In our experience of 46 pneumonectomies with carina resection the five-year survival is 20% and 41% only for the N1 tumors. When there is involvement of the mediastinal ipsilateral nodes we try to do surgery as often as possible (mediastinoscopy is used very routinely now). On 284 N2 primary lung tumors operated between 1982 and 1988 the five-year actuarial survival is 18%. When the pulmonary function is poor we perform lung lobectomies with sleeve resection (114 sleeve resections on the 2255 lobectomies). The postoperative morbidity and mortality is very low in our experience, and the five-year survival is very good (about 40%).

摘要

手术是原发性肺癌的最佳治疗方案。必要时手术范围必须足够大,而当肺功能较差时则必须尽可能缩小。手术对原发性肺癌疗效最佳,但必要时,尤其是对于N2期肿瘤,必须联合辅助治疗。根据我们在玛丽·拉内隆格中心的经验,1966年至1987年间我们共为5890例原发性肺癌患者实施了手术(2255例肺叶切除术和2240例全肺切除术)。我们的长期结果是三年生存率为38%,五年生存率为31%。许多患者接受了扩大手术。必要时在肺切除的同时进行胸壁切除。如有必要也可进行隆突切除。根据我们46例全肺切除并隆突切除的经验,五年生存率为20%,仅N1期肿瘤患者的五年生存率为41%。当同侧纵隔淋巴结受累时,我们尽可能尝试进行手术(现在纵隔镜检查非常常用)。1982年至1988年间对284例N2期原发性肺癌肿瘤患者实施手术,其五年精算生存率为18%。当肺功能较差时,我们采用袖状切除术进行肺叶切除(在2255例肺叶切除术中进行了114例袖状切除术)。根据我们的经验,术后发病率和死亡率非常低,五年生存率非常高(约40%)。

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