Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Mol Biol Cell. 2012 Dec;23(24):4664-7. doi: 10.1091/mbc.E12-10-0716.
The advent of ultra-high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16-40 nucleotides in size. We will highlight how some of these non-micro-short RNAs were discovered, as well as their biogenesis, potential mechanisms of action, and role in diverse biological processes, development, and disease. Finally, we will describe what must be done to further our understanding of these enigmatic molecules.
高通量测序的出现导致了一大组非 microRNA 的小非编码 RNA 的发现。microRNA 的功能相关性在过去十年中得到了很好的证实。在本观点中，我们专注于由各种功能类别组成的非 microRNA 短 RNA，其大小范围为 16-40 个核苷酸。我们将重点介绍其中一些非 microRNA 短 RNA 是如何被发现的，以及它们的生物发生、潜在的作用机制以及在不同的生物过程、发育和疾病中的作用。最后，我们将描述必须做些什么来进一步了解这些神秘的分子。
