长链非编码RNA作为分化、发育及疾病的新兴调控因子。
Long non-coding RNAs as emerging regulators of differentiation, development, and disease.
作者信息
Dey Bijan K, Mueller Adam C, Dutta Anindya
机构信息
a Department of Biochemistry and Molecular Genetics ; University of Virginia School of Medicine ; Charlottesville , VA USA.
出版信息
Transcription. 2014;5(4):e944014. doi: 10.4161/21541272.2014.944014. Epub 2014 Oct 30.
Abstract
A significant portion of the mammalian genome encodes numerous transcripts that are not translated into proteins, termed long non-coding RNAs. Initial studies identifying long non-coding RNAs inferred these RNA sequences were a consequence of transcriptional noise or promiscuous RNA polymerase II activity. However, the last decade has seen a revolution in the understanding of regulation and function of long non-coding RNAs. Now it has become apparent that long non-coding RNAs play critical roles in a wide variety of biological processes. In this review, we describe the current understanding of long non-coding RNA-mediated regulation of cellular processes: differentiation, development, and disease.
摘要
哺乳动物基因组的很大一部分编码了许多未翻译成蛋白质的转录本，这些转录本被称为长链非编码RNA。最初鉴定长链非编码RNA的研究推断，这些RNA序列是转录噪声或RNA聚合酶II随机活性的结果。然而，在过去十年中，人们对长链非编码RNA的调控和功能的理解发生了革命性的变化。现在已经很明显，长链非编码RNA在多种生物学过程中发挥着关键作用。在这篇综述中，我们描述了目前对长链非编码RNA介导的细胞过程调控的理解：分化、发育和疾病。
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