Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
Analyst. 2011 Dec 21;136(24):5134-8. doi: 10.1039/c1an15772h. Epub 2011 Oct 19.
A novel method is developed to fabricate the polypyrrole (PPy) and graphene thin films on electrodes by electrochemical polymerization of pyrrole with graphene oxide (GO) as a dopant, followed by electrochemical reduction of GO in the composite film. The composite of PPy and electrochemically reduced graphene oxide (eRGO)-modified electrode is highly sensitive and selective toward the detection of dopamine (DA) in the presence of high concentrations of ascorbic acid (AA) and uric acid (UA). The sensing performance of the PPy/eRGO-modified electrode is investigated by differential pulse voltammetry (DPV), revealing a linear range of 0.1-150 μM with a detection limit of 23 nM (S/N = 3). The practical application of the PPy/eRGO-modified electrode is successfully demonstrated for DA determination in human blood serum.
开发了一种新方法，通过以氧化石墨烯（GO）为掺杂剂的吡咯电化学聚合，在电极上制备聚吡咯（PPy）和石墨烯薄膜，然后在复合薄膜中电化学还原 GO。PPy 和电化学还原氧化石墨烯（eRGO）修饰电极的复合物对多巴胺（DA）在高浓度抗坏血酸（AA）和尿酸（UA）存在下的检测具有高灵敏度和选择性。通过差分脉冲伏安法（DPV）研究了 PPy/eRGO 修饰电极的传感性能，发现其线性范围为 0.1-150 μM，检测限为 23 nM（S/N = 3）。成功地将 PPy/eRGO 修饰电极用于人血清中 DA 的测定。
