Moffatt Samuel Edwin
University of Leicester Medical School, Leicester, UK.
Emerg Med J. 2013 Dec;30(12):989-96. doi: 10.1136/emermed-2012-201883. Epub 2012 Dec 14.
Hypovolaemic shock that results through traumatically inflicted haemorrhage can have disastrous consequences for the victim. Initially the body can compensate for lost circulating volume, but as haemorrhage continues compensatory mechanisms fail and the patient's condition worsens significantly. Hypovolaemia results in the lethal triad, a combination of hypothermia, acidosis and coagulopathy, three factors that are interlinked and serve to worsen each other. The lethal triad is a form of vicious cycle, which unless broken will result in death. This report will focus on the role of hypothermia (a third of the lethal triad) in trauma, examining literature to assess how prehospital temperature control can impact on the trauma patient. Spontaneous hypothermia following trauma has severely deleterious consequences for the trauma victim; however, both active warming of patients and clinically induced hypothermia can produce particularly positive results and improve patient outcome. Possible coagulopathic side effects of clinically induced hypothermia may be corrected with topical haemostatic agents, with the benefits of an extended golden hour given by clinically induced hypothermia far outweighing these risks. Active warming of patients, to prevent spontaneous trauma induced hypothermia, is currently the only viable method currently available to improve patient outcome. This method is easy to implement requiring simple protocols and contributes significantly to interrupting the lethal triad. However, the future of trauma care appears to lie with clinically induced therapeutic hypothermia. This new treatment provides optimism that in the future the number of deaths resulting from catastrophic haemorrhaging may be significantly lessened.
创伤性出血导致的低血容量性休克对受害者可能会产生灾难性后果。最初,身体能够代偿循环血量的丢失,但随着出血持续,代偿机制失效,患者的病情会显著恶化。低血容量会导致致死三联征,即体温过低、酸中毒和凝血功能障碍,这三个因素相互关联且相互恶化。致死三联征是一种恶性循环,除非被打破,否则将导致死亡。本报告将聚焦于体温过低(致死三联征的三分之一)在创伤中的作用,查阅文献以评估院前体温控制如何影响创伤患者。创伤后自发的体温过低对创伤受害者有严重的有害后果;然而,对患者进行主动复温以及临床诱导低温都能产生特别积极的效果并改善患者预后。临床诱导低温可能产生的凝血功能障碍副作用可用局部止血剂纠正,临床诱导低温所带来的延长的黄金救援时间的益处远远超过这些风险。对患者进行主动复温以预防创伤后自发的体温过低,是目前改善患者预后唯一可行的方法。这种方法易于实施,只需简单的方案,并且对打断致死三联征有显著作用。然而,创伤护理的未来似乎在于临床诱导治疗性低温。这种新疗法让人乐观地认为,未来因灾难性出血导致的死亡人数可能会大幅减少。