George E. Wahlen Veteran Affairs Medical Center, University of Utah, Division of Rheumatology, Salt Lake City, UT, USA.
J Clin Sleep Med. 2012 Dec 15;8(6):643-8. doi: 10.5664/jcsm.2254.
Sleep disturbances, including obstructive sleep apnea (OSA), commonly limit function and quality of life in people with spondyloarthritis (SpA). Systemic inflammation has been implicated in the pathophysiology of both OSA and SpA, and suppression of inflammation with tumor necrosis factor α (TNF) inhibitors may decrease OSA severity. In this study, we compared the frequency of OSA in patients receiving and not receiving TNF-inhibitor therapy.
Data were collected from 63 consecutively screened veterans with SpA. Participant interviews, examinations, chart reviews, and referrals to the Salt Lake City Veteran Affairs (SLCVA) Sleep Center were used to obtain demographic data, comorbidities, SpA features, therapy data, and sleep study outcomes.
OSA occurred in 76% of SpA patients. OSA was less common in patients receiving TNF-inhibitor therapy (57%), compared to patients not receiving TNF-inhibitor therapy (91%) (p = 0.01).
OSA is underrecognized in veterans with SpA, and TNF-inhibition was associated with a lower frequency of OSA.
睡眠障碍，包括阻塞性睡眠呼吸暂停（OSA），常限制脊柱关节炎（SpA）患者的功能和生活质量。全身性炎症与 OSA 和 SpA 的病理生理学有关，而肿瘤坏死因子 α（TNF）抑制剂抑制炎症可能会降低 OSA 的严重程度。在这项研究中，我们比较了接受和未接受 TNF 抑制剂治疗的患者中 OSA 的发生频率。
从连续筛查的 63 名 SpA 退伍军人中收集数据。通过对退伍军人的访谈、检查、病历回顾以及向盐湖城退伍军人事务部（SLCVA）睡眠中心转诊，获取人口统计学数据、合并症、SpA 特征、治疗数据和睡眠研究结果。
76%的 SpA 患者存在 OSA。接受 TNF 抑制剂治疗的患者中 OSA 的发生率（57%）明显低于未接受 TNF 抑制剂治疗的患者（91%）（p = 0.01）。
SpA 退伍军人中 OSA 认识不足，TNF 抑制与 OSA 发生率降低有关。
