Ciccone Marco Matteo, Scicchitano Pietro, Zito Annapaola, Cortese Francesca, Boninfante Barbara, Falcone Vito Antonio, Quaranta Vitaliano Nicola, Ventura Valentina Anna, Zucano Antonietta, Di Serio Francesca, Damiani Mario Francesco, Resta Onofrio
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari 70124, Italy.
Institute of Respiratory Disease, University of Bari, Bari 70124, Italy.
Molecules. 2014 Jan 29;19(2):1651-62. doi: 10.3390/molecules19021651.
Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder associated with the development of cardiovascular diseases and atherosclerosis. Systemic inflammation plays an important role in the development of cardiovascular complications in OSA patients. The aim of the study was to evaluate the relationship between carotid intima-media thickness (cIMT) and inflammatory markers plasma levels in OSA patients. We enrolled 80 OSA patients and 40 controls matched for age and body mass index (BMI). The presence and severity of sleep apnea was determined by in-laboratory portable monitoring (PM). Demographic data, blood pressure, heart rate, and cIMT were measured. High-sensitive C-Reactive Protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α and pentraxin (PTX)-3 serum concentrations were detected. cIMT was higher in OSA patients than controls (0.89 ± 0.13 mm vs. 0.65 ± 0.1 mm, p < 0.01). Moderate-severe OSA patients (0.95 ± 0.09 mm) had significantly increased cIMT than mild OSA (0.76 ± 0.1 mm; p < 0.01) and control (0.65 ± 0.1 mm; p < 0.01). hsCRP, IL-6, TNF-α, and PTX-3 in patients with OSA (1.67 ± 0.66 mg/L, 2.86 ± 1.39 pg/mL, 20.09 ± 5.39 pg/mL, 2.1 ± 0.59 ng/mL, respectively) were significantly higher than in controls (1.08 ± 0.53 mg/L, p < 0.01; 1.5 ± 0.67 pg/mL, p < 0.01; 12.53 ± 3.48 pg/mL, p < 0.01; 1.45 ± 0.41 ng/mL, p < 0.01, respectively). Carotid IMT was significantly correlated to CRP (r = 0.44; p < 0.01), IL-6 (r = 0.42; p < 0.01), TNF-α (r = 0.53; p < 0.01), and PTX-3 (r = 0.49; p < 0.01). OSA patients showed increased cIMT, CRP, IL-6, TNF-α, and PTX-3 levels. Inflammatory markers levels are correlated to cIMT in OSA patients.
阻塞性睡眠呼吸暂停（OSA）是一种与心血管疾病和动脉粥样硬化发展相关的睡眠呼吸障碍。全身炎症在OSA患者心血管并发症的发展中起重要作用。本研究的目的是评估OSA患者颈动脉内膜中层厚度（cIMT）与炎症标志物血浆水平之间的关系。我们纳入了80例OSA患者和40例年龄及体重指数（BMI）匹配的对照组。通过实验室便携式监测（PM）确定睡眠呼吸暂停的存在和严重程度。测量人口统计学数据、血压、心率和cIMT。检测高敏C反应蛋白（hsCRP）、白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和五聚素（PTX）-3的血清浓度。OSA患者的cIMT高于对照组（0.89±0.13毫米对0.65±0.1毫米，p<0.01）。中重度OSA患者（0.95±0.09毫米）的cIMT显著高于轻度OSA患者（0.76±0.1毫米；p<0.01）和对照组（0.65±0.1毫米；p<0.01）。OSA患者的hsCRP、IL-6、TNF-α和PTX-3（分别为1.67±0.66毫克/升、2.86±1.39皮克/毫升、20.09±5.39皮克/毫升、2.1±0.59纳克/毫升）显著高于对照组（分别为1.08±0.53毫克/升，p<0.01；1.5±0.67皮克/毫升，p<0.01；12.53±3.48皮克/毫升，p<0.01；1.45±0.41纳克/毫升，p<0.01）。颈动脉IMT与CRP（r=0.44；p<0.01）、IL-6（r=0.42；p<0.01）、TNF-α（r=0.53；p<0.01）和PTX-3（r=0.49；p<0.01）显著相关。OSA患者的cIMT、CRP、IL-6、TNF-α和PTX-3水平升高。炎症标志物水平与OSA患者的cIMT相关。
