Department of Chest Diseases, Faculty of Medicine, Hatay Mustafa Kemal University, Tayfur Sökmen (31060) Campus, Alahan-Antakya, 31060, Hatay, Turkey.
Department of Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Antakya, Hatay, Turkey.
Sleep Breath. 2023 Mar;27(1):275-282. doi: 10.1007/s11325-022-02616-z. Epub 2022 Apr 27.
The purpose of the study was to examine the effects of continuous positive airway pressure (CPAP) treatment on inflammation parameters in patients with obstructive sleep apnea syndrome (OSAS).
Patients aged 18 to 65 years who underwent polysomnography (PSG) in the sleep clinic between January 1, 2019, and December 31, 2019, were included in the study. Patients with severe OSAS initiated treatment with CPAP. Patients and control subjects were assessed for levels of periostin, TNF-alpha, TGF-beta, and IL-6. Patients were re-evaluated 3 months later. Comparisons for the serum markers were made between controls and patients of different severity of OSAS. Comparisons of serum markers were also made between baseline and 3 month follow-up. RESULTS: A total of 92 patients were enrolled in the study, including 25 controls (apnea-hypopnea index or AHI < 5/h), 39 patents with mild to moderate OSAS who did not receive CPAP, and 28 patients with severe OSAS receiving CPAP treatment. When all three groups were compared, levels of periostin, TNF-alpha, TGF-beta, and IL-6, as inflammatory markers, were higher in the OSAS group, though not at a statistically significant level. In patients with severe OSAS, there were statistically significant decreases in the TGF-beta 1, TNF-alpha, and IL-6 values between baseline values and the same measures taken after 3 months of CPAP treatment. Periostin values also decreased after treatment, but this decrease was not at a significant level.
Inflammatory parameters of patients with OSAS were significantly higher compared with healthy participants. Regression of inflammation was detected after CPAP treatment.
本研究旨在探讨持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停综合征（OSAS）患者炎症参数的影响。
本研究纳入了 2019 年 1 月 1 日至 12 月 31 日期间在睡眠诊所进行多导睡眠图（PSG）检查的年龄在 18 至 65 岁的患者。患有重度 OSAS 的患者开始接受 CPAP 治疗。评估患者和对照组periostin、TNF-α、TGF-β和 IL-6 的水平。3 个月后对患者进行重新评估。比较不同严重程度 OSAS 患者和对照组之间的血清标志物水平。比较基线和 3 个月随访时的血清标志物水平。
共有 92 例患者入组本研究，包括 25 例对照组（呼吸暂停低通气指数或 AHI<5/h）、39 例未接受 CPAP 治疗的轻中度 OSAS 患者和 28 例接受 CPAP 治疗的重度 OSAS 患者。当比较这三组时，OSAS 组作为炎症标志物的 periostin、TNF-α、TGF-β 和 IL-6 水平更高，但无统计学意义。在重度 OSAS 患者中，CPAP 治疗 3 个月后，TGF-β1、TNF-α和 IL-6 值与基线值相比有统计学意义的下降。periostin 值也在治疗后下降，但无统计学意义。
与健康参与者相比，OSAS 患者的炎症参数明显更高。CPAP 治疗后炎症有消退迹象。
