癌症纳米颗粒的历程：从注射部位到作用部位
Odyssey of a cancer nanoparticle: from injection site to site of action.
作者信息
Nichols Joseph W, Bae You Han
机构信息
Department of Bioengineering, University of Utah, Salt Lake City, UT 84108.
出版信息
Nano Today. 2012 Dec 1;7(6):606-618. doi: 10.1016/j.nantod.2012.10.010.
Abstract
No chemotherapeutic drug can be effective until it is delivered to its target site. Nano-sized drug carriers are designed to transport therapeutic or diagnostic materials from the point of administration to the drug's site of action. This task requires the nanoparticle carrying the drug to complete a journey from the injection site to the site of action. The journey begins with the injection of the drug carrier into the bloodstream and continues through stages of circulation, extravasation, accumulation, distribution, endocytosis, endosomal escape, intracellular localization and-finally-action. Effective nanoparticle design should consider all of these stages to maximize drug delivery to the entire tumor and effectiveness of the treatment.
摘要
任何化疗药物在送达靶点之前都不会有效。纳米级药物载体旨在将治疗或诊断物质从给药点运输到药物作用部位。这项任务要求携带药物的纳米颗粒完成从注射部位到作用部位的旅程。旅程始于将药物载体注入血液，并持续经历循环、渗出、积累、分布、内吞、内体逃逸、细胞内定位，最终发挥作用等阶段。有效的纳米颗粒设计应考虑所有这些阶段，以最大限度地将药物递送至整个肿瘤并提高治疗效果。
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