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用于癌症治疗的尺寸可变换纳米治疗剂。

Size-transformable nanotherapeutics for cancer therapy.

作者信息

Ma Teng, Tran Tuyen Ba, Lin Ethan, Hunt Stephanie, Haveman Riley, Castro Kylie, Lu Jianqin

机构信息

Skaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, the University of Arizona, Tucson 85721, AZ, USA.

Clinical and Translational Oncology Program, the University of Arizona Cancer Center, Tucson 85721, AZ, USA.

出版信息

Acta Pharm Sin B. 2025 Feb;15(2):834-851. doi: 10.1016/j.apsb.2024.11.012. Epub 2024 Nov 25.

DOI:10.1016/j.apsb.2024.11.012
PMID:40177555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11959941/
Abstract

The size of nanodrugs plays a crucial role in shaping their chemical and physical characteristics, consequently influencing their therapeutic and diagnostic interactions within biological systems. The optimal size of nanomedicines, whether small or large, offers distinct advantages in disease treatment, creating a dilemma in the selection process. Addressing this challenge, size-transformable nanodrugs have surfaced as a promising solution, as they can be tailored to entail the benefits associated with both small and large nanoparticles. In this review, various strategies are summarized for constructing size-transformable nanosystems with a focus on nanotherapeutic applications in the field of biomedicine. Particularly we highlight recent research developments in cancer therapy. This review aims to inspire researchers to further develop various toolboxes for fabricating size-transformable nanomedicines for improved intervention against diverse human diseases.

摘要

纳米药物的尺寸在塑造其化学和物理特性方面起着至关重要的作用，从而影响它们在生物系统中的治疗和诊断相互作用。纳米药物的最佳尺寸，无论是小尺寸还是大尺寸，在疾病治疗中都具有独特的优势，这在选择过程中造成了两难困境。为应对这一挑战，尺寸可转变的纳米药物已成为一种有前景的解决方案，因为它们可以进行定制，兼具与小尺寸和大尺寸纳米颗粒相关的优势。在这篇综述中，总结了构建尺寸可转变纳米系统的各种策略，重点是生物医学领域的纳米治疗应用。特别值得一提的是，我们突出了癌症治疗方面的最新研究进展。这篇综述旨在激励研究人员进一步开发各种工具包，以制造尺寸可转变的纳米药物，从而更好地干预各种人类疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/b48e96a5c318/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/a37081f069de/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/e58391bce46a/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/e693844b0311/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/a0923c16d154/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/5ffea1a7f67d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/1c890ae36f52/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/e8f6c762c9b2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/11be65ee3c08/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/1fd5f774e025/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/b48e96a5c318/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/a37081f069de/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/e58391bce46a/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/e693844b0311/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/a0923c16d154/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/5ffea1a7f67d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/1c890ae36f52/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/e8f6c762c9b2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/11be65ee3c08/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/1fd5f774e025/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d31/11959941/b48e96a5c318/gr8.jpg

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2
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Nanomicro Lett. 2024 Feb 1;16(1):103. doi: 10.1007/s40820-023-01313-0.
3
Tumor Abnormality-Oriented Nanomedicine Design.肿瘤导向的纳米医学设计。
Chem Rev. 2023 Sep 27;123(18):10920-10989. doi: 10.1021/acs.chemrev.3c00062. Epub 2023 Sep 15.
4
Phototriggered structures: Latest advances in biomedical applications.光触发结构：生物医学应用的最新进展。
Acta Pharm Sin B. 2023 Jul;13(7):2844-2876. doi: 10.1016/j.apsb.2023.04.005. Epub 2023 Apr 17.
5
Magnetosome-inspired synthesis of soft ferrimagnetic nanoparticles for magnetic tumor targeting.受磁小体启发的软铁磁性纳米粒子的合成及其用于磁性肿瘤靶向。
Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2211228119. doi: 10.1073/pnas.2211228119. Epub 2022 Nov 2.
6
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Small. 2022 Dec;18(48):e2204759. doi: 10.1002/smll.202204759. Epub 2022 Oct 26.
7
Reversible assembly of nanoparticles: theory, strategies and computational simulations.纳米颗粒的可逆组装：理论、策略与计算模拟
Nanoscale. 2022 Oct 13;14(39):14385-14432. doi: 10.1039/d2nr02640f.
8
Nucleobase-Interaction-Directed Biomimetic Supramolecular Self-Assembly.碱基相互作用导向的仿生超分子自组装。
Acc Chem Res. 2022 Jun 21;55(12):1609-1619. doi: 10.1021/acs.accounts.2c00135. Epub 2022 Jun 7.
9
Acid-Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer.用于食管癌放射增敏和协同放化疗的酸响应性聚集金纳米颗粒
Small. 2022 May;18(19):e2200115. doi: 10.1002/smll.202200115. Epub 2022 Mar 9.
10
When imaging meets size-transformable nanosystems.当成像技术遇上可改变尺寸的纳米系统时。
Adv Drug Deliv Rev. 2022 Apr;183:114176. doi: 10.1016/j.addr.2022.114176. Epub 2022 Feb 25.