Schulz Ramona, Dobbelstein Matthias, Moll Ute M
Department of Molecular Oncology; Göttingen Center of Molecular Biosciences; University of Göttingen; Göttingen, Germany.
Oncoimmunology. 2012 Nov 1;1(8):1425-1426. doi: 10.4161/onci.21173.
Constitutively stabilized HSP90 client proteins are crucial for cancer cell survival and proliferation. Thus, despite-or perhaps because of-their pleiotropic effects on variety of critical oncoproteins, HSP90 inhibitors represent a promising new class of anticancer drugs. We identified MIF as an essential HSP90 client protein in a murine model of Her2-overexpressing breast cancer.
组成型稳定的HSP90客户蛋白对癌细胞的存活和增殖至关重要。因此，尽管HSP90抑制剂对多种关键癌蛋白具有多效性作用，或者也许正是因为这种多效性作用，它们代表了一类有前景的新型抗癌药物。在HER2过表达乳腺癌的小鼠模型中，我们将巨噬细胞移动抑制因子鉴定为一种必需的HSP90客户蛋白。
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